垦喳量塑堂壅查垫!!堡!旦箜!!鲞箜!塑!璺!』Q壁垒!E：』!!z!!：!!!!：坠!：!!：№：!帕瑞昔布对骨科术后镇痛的疗效观察罗华云陈崇伟吕智【摘要】目的观察帕瑞昔布在骨科术后镇痛治疗中的疗效及安全性。方法选择2009年1～12月间骨科四肢手术后24h内急性疼痛患者6()例．随机分为肌注帕瑞昔布(40nag)组和肌注哌替啶(50rng)组，对比分析两组的急性疼痛缓解程度、疼痛缓解时间和不良反应发生率。选择2009年1～12月间骨科全麻术后患者60例，随机分为肌注帕瑞昔布(40mg。bid)组和自控静脉镇痛泵组。观察两组术后24h内镇痛效果及不良反应发生率。采用疼痛视觉模拟评分法评价疼痛程度。结果在术后急性疼痛镇痛中，肌注帕瑞昔布40mg的效果与肌注哌替啶50mg相当。但帕瑞昔布比哌替啶起效快，且疼痛缓解时间长，不良反应发生率低。在术后24h内镇痛中。肌注帕瑞昔布(40mg，bid)的效果与使用静脉镇痛泵相似，但不良反应发生率低。结论帕瑞昔布具有高效和安全的镇痛特性。适合于骨科术后镇痛。【关键词】帕瑞昔布；环氧化酶一2抑制剂；骨科术后疼痛；镇痛D[)I：10．3969／j．issn．1673-7083．2010．04．018Efficacyoflmreeoxibintreatmentofpostoperativepainof哪thop旅patientsLUOHua-yun，CHENChong-钍xoi，LUZhi．DepartmentofOrthopaedics，TheSecondHospital，ShanxiMedicalUniversity，1aiyuan030001，CAinaU慨raal0嗡咖Toa麟theeffectivenessandsafetyofeyclooxygenase-2(ODX-2)inhibitorpareeoxibas8nanalgesicinorthopaedicpostoperativepatients．MethmlsFromJarLtODec．2009。sixtylimboperativepatientswithacutepostoperativepaininOLU"hospitalweresdectedanddividedrandomlyintotwogroups，parecoxib(40mg)madministereda5thepostoperativeanalgesiainexperimentgroupandthepstbidine(50mg)incontrolgroup，thedegreeandtimeofpainalleviatationandtheincidenceofadverseeffectsWel"estatisticallycomparedintwogroups．Moreover．sixtygenera]anesthesiapatients、^，e陀selectedanddividedrandomlyintotwogroups．parecoxib(40mg。bid)wasadministeredasthepostoperativeanalgesiainexperimentgroupandpatientcontrolledintravenousanalgesia(PCIA)incontrolgroup．theanalgesiaeffectandtheincidenceofadverseeffectswerestatisticallycDmparedwithinfirst24h01．tr$afteroperation．ResultsForacutepostoperativepain．theeffectsofpareeoxib(4...
