有机化学ChineseJournalofOrganicChemistryREVIEW*Correspondingauthors.E-mail:gaoguii@163.com;zhouxin@hebau.edu.cnReceivedJune23,2022;revisedJune31,2022;publishedonlineSeptember8,2022.ProjectsupportedbytheGraduateStudentInnovationAbilityTrainingProjectofHebeiProvince(No.CXZZSS2022101).2022年河北省在读研究生创新能力培养(No.CXZZSS2022101)资助项目.94http://sioc-journal.cn/©2023ShanghaiInstituteofOrganicChemistry,ChineseAcademyofSciencesChin.J.Org.Chem.2023,43,94～111DOI:10.6023/cjoc202206044综述与进展基于1,3-二氯-7-羟基-9,9-二甲基-2(9H)-吖啶酮(DDAO)的近红外荧光探针研究进展马延慧武宇乾王晓旭高贵*周欣*(河北农业大学理工学院河北沧州061100)摘要1,3-二氯-7-羟基-9,9-二甲基-2(9H)-吖啶酮(DDAO)是一种优异的近红外荧光染料,具有近红外发射、低pKa值(≈5.0)、高水溶性以及高量子产率(Φ＝0.39),近年来在荧光探针领域受到广泛关注.研究证明,以该染料设计合成的荧光探针可以在温和的水溶液中工作,具有反应迅速、选择性和灵敏度高、检测限低以及比色信号变化明显等优异的传感性能.此外,该类探针的细胞毒性低,对于活细胞和生物体的检测具有显著的应用价值.综述了基于DDAO及其衍生物的荧光探针的研究进展,主要包括探针在生物酶、活性氧、活性氮、蛋白质以及Pd0的识别检测中的分子设计、作用机理和应用,并对该类荧光探针的发展前景进行了展望.关键词1,3-二氯-7-羟基-9,9-二甲基-2(9H)-吖啶酮(DDAO);荧光探针;近红外;检测ResearchProgressofNear-InfraredFluorescentProbesBasedon1,3-Dichloro-7-hydroxy-9,9-dimethyl-2(9H)-acridone(DDAO)Ma,YanhuiWu,YuqianWang,XiaoxuGao,Gui*Zhou,Xin*(CollegeofScienceandTechnology,HebeiAgriculturalUniversity,Cangzhou,Hebei061100)Abstract1,3-Dichloro-7-hydroxy-9,9-dimethyl-2(9H)-acridone(DDAO)isanexcellentnear-infraredfluorescentdyewithnear-infraredemission,lowpKa(≈5.0),highwatersolubilityandhighquantumyield(Φ＝0.39),whichhasattractedmuchattentioninrecentyearsinthefieldoffluorescentprobes.Theresearchesprovethatthefluorescentprobesdesignedandsynthesizedbasedonthisdyecanworkinmildaqueoussolutions,andhaveexcellentsensingperformance,suchasrapidreaction,highselectivityandsensitivity,lowdetectionlimitandobviouscolorimetric...
