过敏性鼻炎/哮喘患者血清白介素-33和胸腺基质淋巴细胞生成素水平分析孔瑞,李赫,赵义(首都医科大学宣武医院风湿免疫-变态反应科,北京100053)DOI:10.11748/bjmy.issn.1006-1703.2022.11.008收稿日期:2022-03-31;修回日期:2022-09-11基金项目:2021年度宣武医院自然科学青年培育项目(编号:QNPY2020012)通讯作者:赵义。E-mail:zy85070@xwhosp.org摘要:目的探索呼吸道过敏患者血清2型炎症因子白介素-33(interleukin33,IL-33)和胸腺基质淋巴细胞生成素(thymicstromallymphopoietin,TSLP)表达水平的影响因素,为临床诊疗提供参考。方法纳入仅单一过敏原过敏的鼻炎和/或哮喘患者76例以及无过敏性疾病对照10例,按照过敏原类型分为尘螨组、狗毛组、蒿花粉组和对照组,比较各组之间血清IL-33和TSLP水平差异,并对尘螨、狗毛、蒿花粉过敏组患者血清过敏原特异性IgE(specificIgE,sIgE)水平和年龄与IL-33和TSLP水平进行相关性分析,并比较不同性别患者上述细胞因子的表达差异。结果蒿花粉组血清IL-33水平明显高于对照组(P<0.05),尘螨组和蒿花粉组患者血清TSLP水平明显高于对照组(均P<0.05);sIgE水平和年龄与两种细胞因子的表达水平无关(P>0.05);男女之间两种细胞因子的水平差异无统计学意义(均P>0.05)。结论过敏原类型会影响炎症应答的水平,而sIgE、性别和年龄对炎症应答水平影响不大。关键词:过敏性鼻炎/哮喘;白细胞介素-33;胸腺基质淋巴细胞生成素;过敏原中图分类号:R593.1;R256.12文献标识码:AAnAnalysisofSerumInterleukin-33andThymicStromalLymphopoietinLevelsinAllergicRhinitis/AsthmaPatientsKONGRui,LIHe,ZHAOYi(DepartmentofRheumatology-Allergy,XuanwuHospitalCapitalMedicalUniversity,Beijing100053,China)Abstract:ObjectiveToexploretheinfluencingfactorsofserumtype2inflammatoryfactorinterleukin-33(IL-33)andthymicstromallymphopoietin(TSLP)expressionsinpatientswithrespiratoryallergy,andtoprovidereferencesforclinicaldiagnosisandtreatment.MethodsSeventy-sixpatientswithrhinitisand/orasthmawhowereallergictoonlyoneallergenand10controlswithoutallergicdiseasewereenrolledforthestudy.Accordingtoallergentypes,thesepatientsweredividedintothedustmitegroup,doghairgroup,Artemisiapollengroupandcontrolgroup,andthedifferencesofserumIL-33andTSLPlevelsamongthesegroupswereevaluated.Thecorrelationofserumallergen-speci...
