2023年2月第30卷第2期腹腔镜下射频消融联合静脉化疗对肝癌患者血清肿瘤标志物及预后的影响周翰宗1，马晓飞1，张俊杰1，高白1，李瑞君1，王敏1*，张应选2［1河南中医药大学第五临床医学院（郑州人民医院）普通外科，河南郑州450003；2郑州大学第一附属医院肝胆外科，河南郑州450052］【摘要】目的探讨腹腔镜下射频消融术（LRFA）联合静脉化疗在肝癌患者中的应用效果。方法82例肝癌患者随机分为两组各41例，对照组予以静脉化疗，观察组予以LRFA联合静脉化疗，比较两组的血清肿瘤标志物、肝功能、并发症。结果治疗后，观察组的血清肿瘤标志物［肝癌高表达基因10（PEG10）、甲胎蛋白（AFP）、糖蛋白抗原19（CA19）］以及肝功能指标［谷草转氨酶（AST）、丙氨酸氨基转移酶（ALT）］水平均低于对照组（P＜0．05）。两组的并发症发生率比较，差异无统计学意义（P＞0．05）。结论LRFA联合静脉化疗治疗肝癌患者的效果确切，可消除癌细胞，恢复肝功能，且并发症较少。【关键词】肝癌；腹腔镜下射频消融术；静脉化疗；肿瘤标志物；肝功能中图分类号：R735.7文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.02.0145ImpactofLaparoscopicRadiofrequencyAblationCombinedwithIntravenousChemotherapyonSerumTumorMarkersandPrognosisofPatientswithLiverCancer//ZHOUHanzong1,MAXiaofei1,ZHANGJunjie1,GAOBai1,LIRuijun1,WANGMin1*,ZHANGYingxuan2[1DepartmentofGeneralSurgery,theFifthClinicalMedicalCollegeofHe'nanUniversityofChineseMedicine(ZhengzhouPeople'sHospital),Zhengzhou450003,China;2DepartmentofHepatobiliarySurgery,theFirstAffiliatedHospitalofZhengzhouUniversity,Zhengzhou450052,China;*Correspondingauthor:WANGMin,E-mail:54695621@qq.com][Abstract]ObjectiveToexploretheapplicationeffectoflaparoscopicradiofrequencyablation(LRFA)combinedwithintravenouschemotherapyinpatientswithlivercancer.Methods82patientswithlivercancerwererandomlydividedintotwogroups,with41casesineachgroup.Thecontrolgroupreceivedintravenouschemotherapy,andtheobservationgroupreceivedLRFAcombinedwithintravenouschemotherapy.Theserumtumormarkers,liverfunctionandcomplicationswerecomparedbetweenthetwogroups.ResultsAftertreatment,thelevelsofserumtumormarkers[livercancerhighexpressiongene10(PEG10),alpha-fetoprotein(AFP),...
