2023年2月第30卷第2期复方甲硝唑栓联合结合雌激素软膏治疗宫颈癌放疗后阴道炎的效果观察吴雄辉，蓝泽锋，陆敏茹（肇庆市第二人民医院妇科，广东肇庆526000）【摘要】目的探讨复方甲硝唑栓联合结合雌激素软膏治疗宫颈癌放疗后阴道炎患者的临床效果。方法选择2019年12月至2021年2月我院收治的宫颈癌放疗后阴道炎患者62例，随机分为两组各31例。在常规冲洗基础上，对照组给予复方甲硝唑栓治疗，观察组给予复方甲硝唑栓联合结合雌激素软膏治疗。比较两组的治疗效果、雌二醇（E2）水平及安全性。结果观察组的治疗总有效率为96.77%，显著高于对照组的74.19%（P＜0.05）。治疗后，两组的E2水平均较治疗前提高，且观察组的E2水平显著高于对照组（P＜0.05）。两组均未发生严重不良反应。结论复方甲硝唑栓联合结合雌激素软膏治疗宫颈癌放疗后阴道炎患者可有效减轻临床症状，改善激素水平，促进恢复，且具有较高的安全性。【关键词】宫颈癌；放疗；阴道炎；复方甲硝唑栓；结合雌激素软膏；雌二醇中图分类号：R711.31文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.02.0185ObservationontheEffectofCompoundMetronidazoleSuppositoryCombinedwithConjugatedEstrogensOintmentintheTreatmentofVaginitisAfterRadiotherapyforCervicalCancer//WUXionghui,LANZefeng,LUMinru(DepartmentofGynecology,ZhaoqingSecondPeople'sHospital,Zhaoqing526000,China)[Abstract]ObjectiveToexploretheclinicaleffectofcompoundmetronidazolesuppositorycombinedwithconjugatedestrogensointmentinthetreatmentofvaginitisafterradiotherapyforcervicalcancer.Methods62patientswithvaginitisafterradiotherapyforcervicalcanceradmittedtoourhospitalfromDecember2019toFebruary2021wereselectedandrandomlydividedintotwogroups,with31casesineachgroup.Onthebasisofroutinewashing,thecontrolgroupwastreatedwithcompoundmetronidazolesuppository,andtheobservationgroupwastreatedwithcompoundmetronidazolesuppositorycombinedwithconjugatedestrogenointment.Thetherapeuticeffect,estradiol(E2)levelandsafetywerecomparedbetweenthetwogroups.ResultsThetotaleffectiverateoftreatmentintheobservationgroupwas96.77%,significantlyhigherthan74.19%inthecontrolgroup(P<0.05).Aftertreatment,theE2levelsofthetwogroupswerehigherthanthosebeforetreatment,andtheE...
