第41卷第6期2022年12月Vol.41,No.6Dec.,2022声学技术TechnicalAcoustics多光谱光声层析技术在肿瘤学中的应用进展郑怡雯，刘梦瑶，姜立新(上海交通大学医学院附属仁济医院超声医学科，上海200127)摘要：多光谱光声层析技术是一种新兴的光声成像技术，兼具光声断层扫描和多光谱成像的优点。该成像技术需要利用内源性和外源性光声成像对比剂进行成像。成像时，激光发射器发射多个波长的激光束照射组织，组织发生热弹性膨胀并产生超声波，将超声换能器接收的光声信号进行后处理，分解光谱信息并重建图像。目前，多光谱光声层析技术已广泛用于多种肿瘤的研究。文章着重介绍光声成像对比剂和多光谱光声层析技术的发展近况以及在临床转化中取得的研究进展。关键词：多光谱光声层析技术；对比剂；肿瘤中图分类号：R445.1文献标志码：A文章编号：1000-3630(2022)-06-0854-08AdvancesintheapplicationofmultispectraloptoacoustictomographyinoncologyZHENGYiwen,LIUMengyao,JIANGLixin(DepartmentofUltrasound，RenJiHospital，ShanghaiJiaoTongUniversitySchoolofMedicine，Shanghai200127，China)Abstract:Multispectraloptoacoustictomographyisanemergingphotoacousticimagingtechnology,whichcombinesthevirtuesofbothphotoacoustictomographyandmultispectralimaging.Thisimagingtechnologyrequirestheuseofphotoacousticimagingcontrastagents,whichcanbedividedintoendogenousandexogenouscategories.Duringimaging,thelaseremitteremitslaserbeamsofmultiplewavelengthstoirradiatethetissue,whichproducesthermoelasticexpansionandultrasonicwaves.Theimagepost-processingalgorithmprocessesthephotoacousticsignalsreceivedbyultrasonictransducers,decomposesspectralinformationandreconstructstheimage.Atpresent,multispectralphotoacoustictomographyhasbeenwidelyusedtostudyseveralkindsoftumors.Thisreviewfocusesontherecentadvancesandclinicaltranslationofphotoacousticimagingcontrastagentsandmultispectralphotoacoustictomography.Keywords:multispectraloptoacoustictomography;contrastagent;tumor0引言多光谱光声层析技术(MultispectralOptoacous‐ticTomography,MSOT)是一种新兴的光声成像技术，结合了多光谱成像(MultispectralImaging)和光声断层扫描(PhotoacousticTomography,PAT)的技术原理，兼具纯光学成像的高分辨率...
