医学分子生物学杂志,2024,21(2):166-170JMedMolBiol,2024,21(2):166-170DOI:10.3870/j.issn.1672-8009.2024.02.012综述资助项目:国家自然科学基金(No.81774132),陕西省中医药“双链融合”中青年科研创新团队建设项目(No.2022-SLRH-LJ-010),陕西省中医药管理局科研项目(No.2021-zz-JC001)通讯作者:晁旭(电话:15353757303,E-mail:172665861@qq.com)ThisworkwassupportedbygrantsfromtheNationalNaturalScienceFoundationofChina(No.81774132),ShaanxiProvinceTraditionalChineseMedicine"DoubleChainIntegration"ResearchandInnovationTeamBuildingProject(No.2022-SLRH-LJ-010),ShaanxiProvinceTraditionalChineseMedicineAdministrationResearchProject(No.2021-zz-JC001)Correspondingauthor:CHAOXu(Tel:86-15353757303,E-mail:172665861@qq.com)let-7i-5p在肿瘤中的研究进展偶勇1,董佳琪1,王斑2,李媛媛2,王树楷1,晁旭21陕西中医药大学陕西省咸阳市,7120002陕西中医药大学第二附属医院陕西省咸阳市,712000【摘要】let-7i-5p是非编码小分子RNA(miRNA)中的一员,它通过多靶点和信号通路来抑制肿瘤的生长、增殖和迁移,还具有调节肿瘤微环境延缓癌症进展和改善肿瘤耐药的作用。文章综述了let-7i-5p在肝癌、乳腺癌、结直肠癌、宫颈癌、鼻咽癌、肾癌和胶质母细胞瘤中的研究进展。有望发掘let-7i-5p成为新肿瘤标志物,为肿瘤的防治提供新策略。【关键词】let-7i-5p;肿瘤;机制研究【中图分类号】Q752ResearchProgressonRoleoflet-7i-5pinTumorOUYong1,DONGJiaqi1,WANGBan2,LIYuanyuan2,WANGShukai1,CHAOXu21ShaanxiUniversityofChineseMedicine,Xianyang,Shaanxi,712000,China2TheSecondAffiliatedHospitalofShaanxiUniversityofChineseMedicane,Xianyang,Shaanxi,712000,China【Abstract】let-7i-5pisamemberofnon-codingsmallmoleculeRNA(miRNA),whichinhib-itstumorgrowth,proliferationandmigrationthroughmultipletargetsandsignalingpathways.Italsohastheeffectofregulatingtumormicroenvironmenttodelaycancerprogressionandimprovetumordrugresistance.Thisarticlereviewstheresearchprogressofthemechanismoflet-7i-5pinlivercancer,breastcancer,coloncancer,cervicalcancer,nasopharyngealcancer,kidneycancerandglioblastoma.Itisexpectedtoexploretherolethatlet-7i-5pcanplayasanewtumormarkertopro-vid...
