·110·中国现代药物应用2024年4月第18卷第7期ChinJModDrugAppl,Apr2024,Vol.18,No.7硫辛酸治疗糖尿病周围神经病变41例疗效观察张硕【摘要】目的探讨硫辛酸治疗糖尿病周围神经病变的临床疗效。方法82例糖尿病周围神经病变患者,将其依据随机数字表法分成对照组和观察组,每组41例。对照组给予常规治疗,观察组在常规治疗基础上给予硫辛酸治疗。对比两组治疗效果、不良反应发生率及治疗前后正中与腓总神经的感觉神经传导速度(SCV)、运动神经传导速度(MCV)。结果治疗结束后,观察组总有效率为95.12%,对照组为80.49%；观察组总有效率显著高于对照组(P<0.05)。治疗后,观察组腓总神经MCV、SCV分别为(39.8±4.8)、(45.5±4.0)m/s,对照组分别为(35.6±4.1)、(39.4±3.8)m/s；观察组正中神经MCV、SCV分别为(48.5±4.9)、(46.8±4.5)m/s,对照组分别为(42.4±4.6)、(41.4±4.2)m/s；观察组正中神经、腓总神经的MCV、SCV均高于对照组(P<0.05)。两组治疗期间不良反应发生率对比,无显著差异(P>0.05)。结论针对糖尿病周围神经病变患者,给予硫辛酸治疗效果好,安全性高,能够有效改善其神经传导速度,临床应用价值突出。【关键词】糖尿病周围神经病变；硫辛酸；神经传导速度DOI：10.14164/j.cnki.cn11-5581/r.2024.07.028ObservationonefficacyoflipoicacidinthetreatmentofdiabeticperipheralneuropathyZHANGShuo.DepartmentofEndocrinology,JinzhouCentralHospital,Jinzhou121000,China【Abstract】ObjectiveToexploretheclinicalefficacyoflipoicacidinthetreatmentofdiabeticperipheralneuropathy.Methods82patientswithdiabeticperipheralneuropathyweredividedintoacontrolgroupandanobservationgroupaccordingtorandomnumbertable,eachgrouphad41cases.Thecontrolgroupreceivedconventionaltreatment,whiletheobservationgroupreceivedlipoicacidtreatmentbasedonthecontrolgroup.Thetherapeuticeffect,incidenceofadversereactions,sensorynerveconductionvelocity(SCV)andmotornerveconductionvelocity(MCV)ofmediannerveandcommonperonealnervebeforeandaftertreatmentwerecomparedbetweenthetwogroups.ResultsAftertreatment,thetotaleffectiveratewas95.12%intheobservationgroupand80.49%inthecontrolgroup;theobservationgrouphadsignificantlyhighertotaleffectiveratethanthecontrolgroup(P<0.05).Aftertreatment,theMCVandSCVofcommonperonealnervewere(...
