2023年2月第30卷第2期紫杉醇、卡铂联合放疗对可切除食管腺癌患者临床疗效的影响分析孙红辉,吴清珍(南阳市第一人民医院放射肿瘤科,河南南阳473000)【摘要】目的分析紫杉醇、卡铂联合放疗对可切除食管腺癌患者临床疗效的影响。方法选取2015年1月至2016年6月我院收治的80例可切除食管腺癌患者,随机分为两组各40例。对照组术前采用紫杉醇、卡铂辅助治疗,观察组术前采用紫杉醇、卡铂联合放疗辅助治疗,比较两组的临床疗效。结果观察组术后1年、3年、5年的无进展生存率分别为82.50%、70.00%、52.50%,术后3年、5年的总生存率分别为87.50%、62.50%,均显著高于对照组的70.00%、52.50%、30.00%、70.00%、45.00%,差异均有统计学意义(P<0.05)。术后5年,两组的生存质量各维度评分均提高,且观察组的生存质量各维度评分均显著高于对照组(P<0.05)。结论紫杉醇、卡铂联合放疗可显著提高可切除食管腺癌患者的临床疗效,改善其生存质量。【关键词】可切除食管腺癌;放疗;紫杉醇;卡铂;生存率;生存质量中图分类号:R735.1文献标识码:Adoi:10.3969/j.issn.1674-4659.2023.02.0209AnalysisontheImpactofPaclitaxelandCarboplatinCombinedwithRadiotherapyontheClinicalEfficacyofPatientswithResectableEsophagealAdenocarcinoma//SUNHonghui,WUQingzhen(DepartmentofRadiationOncology,NanyangFirstPeople'sHospital,Nanyang473000,China)[Abstract]ObjectiveToanalyzetheimpactofpaclitaxelandcarboplatincombinedwithradiotherapyontheclinicalefficacyofpatientswithresectableesophagealadenocarcinoma.Methods80patientswithresectableesophagealadenocarcinomaadmittedtoourhospitalfromJanuary2015toJune2016wereselectedandrandomlydividedintotwogroups,with40casesineachgroup.Thecontrolgroupreceivedadjuvanttherapywithpaclitaxelandcarboplatinbeforesurgery,andtheobservationgroupreceivedadjuvanttherapywithpaclitaxelandcarboplatincombinedwithradiotherapybeforesurgery.Theclinicalefficacywascomparedbetweenthetwogroups.ResultsThe1-year,3-year,and5-yearpostoperativeprogression-freesurvivalratesoftheobservationgroupwere82.50%,70.00%and52.50%,respectively,andthe3-yearand5-yearoverallsurvivalrateswere87.50%and62.50%,respectively,significantlyhigherthan70.00%,52.50%,30.00%,70.0...