BaxPI3K:CrkIICrkLShcGRB2JNKJNKJNK1/2/3MKK4/7IRS-1c-Ablc-Abl14-3-314-3-314-3-314-3-3TAK1ASK1MAPKKKsMAPKKKsHPK1GCKMEKK1/4MLK2/3DLKTpI-2TAO1/2PI3Kγc-JunATF-2Elk-1Smad4p53NFAT4Stat3SOSCdc42RacRhoCdc42RacRasTRAF2DaxxPOSHMLKsMKPsJIP1,2,3HSF1NFATc1Gα12/13TRADDRIPGrowthFactors,UVFasL,UVInflammatoryCytokinesG12/13-coupledReceptorsRTKsGβγBaxCellularStress,γRadiationOxidativeStressApoptosisMitochondrialTranslocation/ApoptosisNONucleusCytoplasmTranscriptionGrowthDifferentiationSurvivalApoptosisSAPK/JNKSignalingCascadeswww.cellsignal.com©2002–2011CellSignalingTechnology,Inc.SAPK/JNKSignalingCascades•createdJanuary2002•revisedNovember2011DirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
