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Cell_Cycle_G1S
Suv39H1MycBMI1Myccdc25AMycp27 Kip1p21 Cip1p53MycSmad3Fox01/3Smad4ATM/ATRp15 INK4Bp16 INK4Ap18 INK4CGSK-3Cyclin DCDK4/6CDK2Chk1/2AktCyclin ERbRbAblE2FE2Fp19 INK4DDP-1DP-1SCFSCFFoxO1HDACDNADamageTGF-ReplicativeSenescenceUltra VioletStress ResponseGrowth Factor WithdrawalGrowth Factor Receptor ActivationUbiquitinationReplicativeSenescenceUbiquitinationUbiquitinationE2F/DP Target Genes:Cyclin E/A,E2F-1/2/3,cdc2,c-Myc,p107,RanGAP,TK,DHFR,PCNA,H2A,etc.ONOFFG1-PHASE R S-PHASEDifferentiationDBEBimFasLTRAILApoptosisHormonesCell Cycle Control:G1/S C 2002 2010 Cell Signaling Technology,Inc.Cell Cycle Control:G1/S Checkpoint created November 2002 revised November 2010Direct Stimulatory ModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomal subunitTranscription FactorTranscriptional StimulationTranscriptional InhibitionTranslocationSeparation of Subunits or Cleavage ProductsJoining of SubunitsDirect Inhibitory ModificationMultistep Stimulatory ModificationMultistep Inhibitory ModificationTentative Stimulatory ModificationTentative Inhibitory ModificationSignaling Pathways K 2003-2010 Cell Signaling Technology,Inc.AcetylaseDeacetylase