STE20kinases,RhoGTPases,TRAFubiquitinligasesASK1,DLK1,MEKK3,MEKK4,MLK3,TAK1,TAO1,TAO2,TPL2,ZAK1MKK4,MKK3,MKK6Stress,cytokines,chemokines,hormones,growthfactorsEGFRFGFR1Nav1.6NHE1PLA2TACEEEA1GDI-2Rabenosyn5CaldesmonHsp27Kerantin8StathminTauTensin1BaxCaspase-3Caspase-8Caspase-9Cdc25ACdc25BCyclinD1CyclinD3FLIPsGSJIP4p47phoxp57Kip2PIP4K�Rpn2Siah2Tab1Tab3JDP2NR4Ap18HamletPGC-1�Rb1RNF2SRC3BAF60cCdt1E47H2AXH3HBP1IUF1TranscriptionfactorDNAbindingRNAbindingSer/ThrkinaseRegulatoryproteinMembraneproteinEndosometraffcStructuralproteinMitochondrialproteinGSK3�MK2MK3MK5Mnk1Mnk2Msk1Msk2PAK6PKC�p38�(MAPK14)BimELLaminB1ATF2C/EBP�C/EBP�C/EPB�CHOPE2F4Elk-1ER�FosFOXO3aGRJunMafAMEF2AMEF2CMEF2DMITFMRF4NFATC4Osterixp53Pax6PPAR�SAP1Smad3Smad9STAT1STAT4Twist1USF1Xbp1sAAAmGpppFBP2FBP3HuRKSRPRps27SPF45PPPPPPPPPPPPSeeonlineversionforlegendandreferences.656Cell152,January31,2013©2013ElsevierInc.DOIhttp://dx.doi.org/10.1016/j.cell.2013.01.029SnapShot:p38MAPKSignalingNataliaTrempolec,1NataliaDave-Coll,1andAngelR.Nebreda1,21InstituteforResearchinBiomedicine(IRBBarcelona),08028Barcelona,Spain2InstitucióCatalanadeRecercaiEstudisAvançats(ICREA),08010Barcelona,Spain656.e1Cell152,January31,2013©2013ElsevierInc.DOIhttp://dx.doi.org/10.1016/j.cell.2013.01.029SnapShot:p38MAPKSignalingNataliaTrempolec,1NataliaDave-Coll,1andAngelR.Nebreda1,21InstituteforResearchinBiomedicine(IRBBarcelona),08028Barcelona,Spain2InstitucióCatalanadeRecercaiEstudisAvançats(ICREA),08010Barcelona,Spainp38:AStress-ActivatedProteinKinasewithMultipleFunctionsMitogen-activatedproteinkinase(MAPK)pathwaysareimportantregulatorsofcellularresponsestomanyextracellularstimuli.Typically,eukaryoticcellshaveseveralparallelMAPKpathways,whichallowtheintegrationofsignalsfromdifferentstimuli.Oneofthese,thep38MAPKpathway,hasbeenconservedfromyeasttomammals,inwhichtherearefourfamilymembers:p38a(MAPK14),p38b(MAPK11),p38d(MAPK13),andp38g(MAPK12).Mostofwhathasbeenpublishedonp38MAPKsignalingreferstop38a,whichisubiquitouslyexpressedathi...
