NIKTAK1TRAF2TRADDFADDPTENPIP3RasSrcJakRafPKCErk1/2PKAp70S6KBadp90RSKCREBStat1Stat3CREBStat1Stat3Bcl-xLBcl-2CytocApaf-1HSP70HSP90HSP90HSP90HSP27HSP27IKKβIκBNF-κBIκBFoxO1FoxO1FoxO1Casp-3,-6,-7Casp-9Casp-8,-10A20CYLDGSK-3JNKXIAPNF-κBNF-κBAktAktPDK1PI3KTNF-R1TNF-αHSP90HSP70IKKγIKKβIKKαIKKγCDC37TABcIAPtBIDBaxBaxBaxFLIPMcl-1HECTH9BimBIDBimBimHSP70HSP27HSP90Smac/Diablo[cAMP]RIPSurvivalFactors:GrowthFactors,Cytokines,etc.ApoptosisFASBimBcl-2Bcl-xLFLIPXIAPA20CytoplasmCytoplasmNucleus©2002–2010CellSignalingTechnology,Inc.InhibitionofApoptosis•createdJanuary2002•revisedNovember2010InhibitionofApoptosiswww.cellsignal.comDirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
