VascularGuidanceVascularPermeabilitySurvivalMigrationProliferationVHLCul2Rbx1TCEB2TCEB1UbUbUbUbUbPHDselF4E14E-BP1Erk1/2Erk1/2MNKMEK1/2RasS6KmTORAktPI3KCBP/p300HIF1αHIF1αHIF1βHIF1βHIF1αPI3KSrcNOSAktFAKPLCγErk1/2Smad2/3p38MAPKHIF1αHIF1αNucleusHRETargetGenesMatrixRemodelingCytoplasmPAI-1MMPCox2NormoxiaOHOHOHTumorCellVEGFR2VEGFPericyteProliferationTie2FGFRIGFRTGFα-RPDGFR-βPDGF-BBROBOSLITE3LigaseComplexDegradation•GrowthFactors•Cytokines•ECMProteasesExtracellularMatrixEndothelialCellCytoplasmPericyteExtracellularSpace©2008–2010CellSignalingTechnology,Inc.Angiogenesis•createdSeptember2008•revisedMarch2011Angiogenesiswww.cellsignal.comDirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
