14-3-3σTopoIIp21Cip1CDK714-3-3Boracdc25cdc25A/Ccdc25A/BPLK1Myt1Wee1p90RSKATM/ATRMre11NBS1Rad52Chk2c-AblPOT1TRF2Chk1DNA-PKcdc25Acdc2CyclinBp53p53MDM2MDM4MDM2AurATRIP12BRCA1BRCA1BRCA1FANCD2Rad50ReprimoGADD45Rad51HIPK2p300/PCAFSCFSCFp19ArfIRUVCriticallyShortTelomeresDNARepairCaffeine(MRN)DNARepairNuclearExclusionNuclearExclusionNucleolarSequestrationorp53StabilizationNuclearExport,UbiquitinationUbiquitinationUbiquitinationG2-PHASEM-PHASECellCycleControl:G2/MDNADamageCheckpointwww.cellsignal.com©2002–2010CellSignalingTechnology,Inc.CellCycleControl:G2/MDNADamageCheckpoint•createdNovember2002•revisedNovember2010DirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
