ru-第5章细胞通讯20171205(1).pptVIP免费

1CHAPTER5细胞通讯CELLCOMMUNICATION2OUTLINE5.1BASICCHARACTERISTICSOFCELL-SIGNALINGSYSTEMS5.2GPROTEINCOUPLEDRECEPTOR5.3SIGNALINGVIAENZYME-LINKEDRECEPTORSANDOTHERSIGNALINGPATHWAY5.4SIGNALCONVERGENT、DIVERGENT、CROSSTALKANDCELLADAPTATION信号出现信号出现传递消息传递消息决策决策执行功能执行功能信息感受信息传递命令传递日常生活中的信息传递细胞通讯：CellCommunication4细胞通讯：CellCommunication细胞间或细胞内通过高精度和高效的接收信息通讯机制并通过放大引起快速的细胞生理反应/或引起基因活动，从而发生一系列的细胞活动来协调各组织行动，使之成为统一生命整体对外界环境变化作出综合应答。5•CellSignal：信号的产生及传送synthesisofsignalmoleculereleasetransportCellCommunicationReaction•SignalTransduction：信号的接收、转换、应答signalrecognitiontransductionresponseTransductionSignalmoleculesrecognition(receptor)ReactionSIGNALINGCOMPONENTSFourTypesofCellCommunicationCell-SurfaceReceptorsFallintoThreeMainClassesTheBasicCellSignalingProcess(A)Contact-dependent:don’tneedsecretedmolecule(B)Papacrine:tonearbyneighbor(C)Neuronalsignaling(D)Endocrine:tolongdistanceFromBruceAlbertsetal.,MolecularBiologyofTheCell(5thedition))Signalcanactoverlongorshortrange.FourTypesofCellCommunicationFromEssentialCellBiology(©GarlandScience2010)FromEssentialCellBiology(©GarlandScience2010)105.1.1CellSignalingandSignalmolecule不依赖于细胞接触：依赖于细胞接触：11TransductionSignalmoleculesrecognition(receptor)Reaction5.1.2SignalRecognitionandReceptors受体（receptor）：任何能够与信号分子结合并能引起细胞功能变化的生物大分子。12接收信息→受体信号分子→配体(ligand)FromBruceAlbertsetal.,MolecularBiologyofTheCell(5thedition)1.Anion-channel-coupledopensorclosesinresponsetobindingofitsextracellularsignalmolecule.Thesechannelsarealsocalled‘transmitter-gatedionchannelsCellsurfacereceptorsfallintothreebasicclassesFromBruceAlbertsetal.,MolecularBiologyofTheCell(5thedition)2.G-protein-coupledreceptor:WhenaG-coupledreceptorbindsitsextracellularsignalmolecule,thesignalispassedfirsttoaGTP-bindingprotein(Gprotein)thati...