第36卷第3期2023年6月华夏医学ActaMedicinaeSinicaVol.36No.3Jun.2023DOI:10.19296/j.cnki.1008-2409.2023-03-008·论著··ORIGINALARTICLE·甲钴胺缓解XELOX方案治疗结直肠癌所致的外周神经损伤①何文广②,陈倩雅,温国华,刘小梨③(广州医科大学附属第四医院普外科,广东广州511300)摘要目的:探讨甲钴胺对XELOX方案治疗结直肠癌所致外周神经病变的作用。方法:将62例结直肠癌患者按照随机数字表法分为两组,每组31例。对照组采用XELOX方案治疗,观察组在对照组基础上加用甲钴胺治疗。比较两组周围神经及预后情况。结果:观察组2级及2级以上周围神经病变发生率低于对照组,发生时间晚于对照组,化疗相关不良反应发生率低于对照组,差异均有统计学意义(P<0.05)。化疗6个周期后,观察组周围神经传导速度快于对照组,CGRP水平高于对照组,NGF水平低于对照组,QOL-C30评分低于对照组,差异均有统计学意义(P<0.05)。观察组无进展生存时间长于对照组,3年生存率高于对照组(P<0.05)。结论:甲钴胺可减轻XELOX方案治疗结直肠癌所致周围神经病变,提高治疗效果。关键词:甲钴胺;结直肠癌;XELOX化疗;周围神经病变;生活质量中图分类号:R453文献标志码:A文章编号:1008-2409(2023)03-0041-06MecobalaminalleviatedperipheralnerveinjurycausedbyXELOXregimeninthetreatmentofcolorectalcancer①HEWenguang②,CHENQianya,WENGuohua,LIUXiaoli③(Dept.ofGeneralSurgery,theFourthAffiliatedHospitalofGuangzhouMedicalUniversity,Guangzhou511300,China)AbstractObjective:ToinvestigatethetherapeuticeffectofmecobalaminonperipheralneuropathyinducedbyXELOXregimeninpatientswithcolorectalcancer.Methods:Accordingtotherandomnumbertablemethod,62patientswithcolorectalcancerwereselectedanddividedintotwogroups,with31patientsineachgroup.ThecontrolgroupweretreatedwithXELOXregimen,andtheobservationgroupweretreatedwithmecobalaminonthebasisofthetreatmentregimeninthecontrolgroup.Theperipheralnervesandprognosiswerecomparedbetweenthetwogroups.Results:Theincidenceofgrade2andaboveperipheralneuropathyintheobservationgroupwaslowerthanthatinthecontrolgroup,theoccurrence·14·①基金项目:广州市科技计划项目(202102080574)。②第一作者简介:何文广,本科,副主任医师,研究方向为普外科微创治疗。③通信作者:刘小梨,E-mail:364480116@qq.com。第3期华夏...
