cancersReviewPyroptosisinCancer:FriendorFoe?XiuxiaLu,TianhuiGuoandXingZhang*�����������������Citation:Lu,X.;Guo,T.;Zhang,X.PyroptosisinCancer:FriendorFoe?Cancers2021,13,3620.https://doi.org/10.3390/cancers13143620AcademicEditor:StephenJ.BeebeReceived:11June2021Accepted:14July2021Published:20July2021Publisher’sNote:MDPIstaysneutralwithregardtojurisdictionalclaimsinpublishedmapsandinstitutionalaffil-iations.Copyright:©2021bytheauthors.LicenseeMDPI,Basel,Switzerland.ThisarticleisanopenaccessarticledistributedunderthetermsandconditionsoftheCreativeCommonsAttribution(CCBY)license(https://creativecommons.org/licenses/by/4.0/).MelanomaandSarcomaMedicalOncologyUnit,StateKeyLaboratoryofOncologyinSouthChina,CollaborativeInnovationCenterforCancerMedicine,SunYat-senUniversityCancerCenter,Guangzhou510060,China;luxx@sysucc.org.cn(X.L.);guoth@sysucc.org.cn(T.G.)*Correspondence:zhangxing@sysucc.org.cnSimpleSummary:Pyroptosisisanewformofprogrammedcelldeaththatdiffersfromapoptosisintermsofitsreleaseofinflammatoryfactorsanditscharacteristicbubble-likemorphology.Pyroptosiswasfirstdiscoveredintheprocessofimmunedefenseagainstbacterialinfection,butthefieldofresearchsoonspreadtootherinflammatorydiseasesandcancer.Ascancerconstitutesaseriousriskforpublichealth,numerousstudiesinvestigatingpyroptosisincancerhavebeencarriedoutduringtheseyears.Tumorigenesisandnewtherapeutictreatmentshavebeenthefocusofmuchrecentresearch.Thisreviewdiscussestheroleofpyroptosisintumorigenesisanditsinfluenceontumorimmunity.Abstract:Pyroptosisisaninflammatoryformofprogrammedcelldeaththatismediatedbypore-formingproteinssuchasthegasderminfamily(GSDMs),includingGSDMA-E.Uponcleavagebyactivatedcaspasesorgranzymeproteases,theN-terminalofGSDMsoligomerizesinmembranestoformpores,resultinginpyroptosis.Thoughallthegasderminproteinshavebeenstudiedincancer,theroleofpyroptosisincancerremainsmysterious,withconflictingfindings.Numerousstudieshaveshownthatvariousstimuli,suchaspathogen-associatedmolecularpatterns(...
