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PI3K-Akt Signaling Interactive Pathway.pdf
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PI3K-Akt Signaling Interactive Pathway PI3K Akt
Cell Signaling Technology 20032016 Cell Signaling Technology,IDirect Stimulatory Modification Direct Inhibitory ModificationMultistep Stimulatory Modification Multistep Inhibitory ModificationTentative Stimulatory Modification Tentative Inhibitory ModificationDirect Inhibitory ModificationMultistep Stimulatory Modification Multistep Inhibitory ModificationTentative Stimulatory Modification Transcriptional Inhibitory ModificationKinase Phosphatase Transcription Factor Caspase Receptor Enzyme pro-apoptotic pro-survival GAP/GEF GTPase G-proteinAcetylaseDeacetylasePathway Diagram KeyPI3 Kinase/Akt SignalingAktATM/ATRDNA-PKAktp70 S6KPI3KPI3KPaxillinGSK-3PHLPP1/2CTMPLamin Ap47phoxPP2ATpl2IKKeNOSGSATP-CitrateLyaseBadBcl-2FoxO1TSC2PDCD4AS160PFKFB2Hexokinase IIPIP5KS6Skp2 SCFp53MDM2BimBaxp27 Kip1p21 Waf1/Cip114-3-3PalladinGirdinCyclin D1GGTPPTENPDK1SykJak1FAKILKPI3KPI3KPI3KXIAPWee1CDK2Myt1Gab1Gab2IRS-1PTENIntegrinCytokineReceptorPDK1GBCAPLynAgAtaxin-1HuntingtinGABAARPRAS40GPCRRTKCD19BCRPIP3PIP3RaptorGLmTORDEPTORmTORC1mTORC2mTORRictorSin1PRR5DEPTORGLmTORC1mTORC24E-BP1ATG13Cyclin ATSC1TRAF6NEDD1-4TBK1/BlocksAggregationPromotesNeuroprotectionSynapticSignalingmIgmIgCytosolicSequestrationCardiovascularHomeostasisNF-BPathwayOrganizationof NuclearProteinsNeutrophilRespiratoryBurstCell CycleApoptosisMigrationAggregationNeurodegenerationInhibits ApoptosisInhibitsAutophagyGlycogenSynthesisFatty AcidSynthesisGlucose TransportGlycolysisMembrane Recruitment and Activation Membrane Recruitmentand ActivationDNA DamageProtein SynthesisSurvivalProliferationMigrationGlucose MetabolismNeuroscienceOther

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