C?hotmail.com病例报著1872023年6月第30卷第3期皮肤性病诊疗学杂志猴痘1例及文献复习杨立刚，安宁波，温韵菁?1.南方医科大学皮肤病医院，广东广州510091;2.广州市疾病预防控制中心，广东广州510440[摘要]目的为了解猴痘的临床表现、检测及诊断方法。方法对近期确诊的1例猴痘患者临床及实验室资料进行分析，并对国内外报道相关病例资料进行回顾。结果此病例为43岁男性患者，发热2～3d后在阴阜及阴茎干出现红斑丘疹，继而形成脓疱，脓疱破溃后局部溃疡。患者既往有梅毒史皮肤科检查：右侧阴阜部红肿明显，红肿部位可见结痴脓疱，阴茎包皮及冠状沟各1处结痴脓疱。皮损、血液、咽喉拭子标本猴痘病毒核酸检测阳性，利用Nextclade工具（参考基因组NC_063383.1）对该序列进行比对、分析结果显示，该序列属于猴痘病毒分支Ⅱ（西非分支）B.1.3型。确诊为猴痘病毒感染。结论猴痘属于新发传染病，根据接触史、临床表现及核酸检测结果可作出诊断。应提高对猴痘临床表现的认识，避免可能发生的漏诊误诊。[关键词]猴痘；生殖器AcaseofmonkeypoxandliteraturereviewYANGLigang',ANNingbo',WENYunjing1.DermatologyHospital,SouthernMedicalUniversity,Guangzhou510091,China;2.GuangzhouCenterforDiseaseControlandPrevention,Guangzhou510440,Chinaorrespondingauthor:YANGLigang,E-mail:yanglg3[Abstract]ObjectiveToinvestigatetheclinicalmanifestations,laboratorytestsanddiagnosisofmonkeypox.MethodsTheclinicalandlaboratorydataofarecentlydiagnosedmonkeypoxpa-tientwereanalyzed,andthedataofreportedcaseswerereviewed.ResultsThiscasewasa43-year-oldmalepatientwitherythemaandpapulesonthepubisandpenis2-3daysafterfever.Therashesbeganwitherythema,followedbypustulesandulcers.Thepatienthadaprevioushistoryofsyphilis.Dermatologicalexaminationrevealederythematousswollenpubicmoundwithpustulesandcrustsontherightsideandapustulewithcrustonboththeforeskinandthecoronaoftheglanspenis.Monkeypoxvirusnucleicacidtestwaspositiveintheskin,bloodandthroatswabsamples.ThegenesequencewascomparedandanalyzedusingtheNextcladetool(referencege-nomeNC_063383.1),andtheresultsshowedthatthesequencewasconsistentwiththatofmon-keypoxviruscladeII(WestAfricanclave),typeB.1.3.Monkeypoxvirusinfectionwascon-firmed.ConclusionsMonk...
