中国病理生理杂志ChineseJournalofPathophysiology2023，39（2）：352-358杂志网址：http://www.cjpp.netYTHDC1m6A修饰调控与疾病发病机制的研究进展*韩韦钰，陈远兴，李超中，刘围围，赵永超，赵然尊△（遵义医科大学附属医院心血管内科，贵州遵义563000）RecentprogressinstudyofYTHDC1m6AmodificationandregulationandpathologicalmechanismofdiseasesHANWeiyu，CHENYuanxing，LIChaozhong，LIUWeiwei，ZHAOYongchao，ZHAORanzun△（DepartmentofCardiovascularMedicine，AffiliatedHospitalofZunyiMedicalUniversity，Zunyi563000，China.E-mail：kouke80@126.com）［ABSTRACT］N6-methyladenosine（m6A）RNAmodificationisakeyfieldinepigenetics，whichisconsideredasakeyregulatorofgeneexpressionandproteintranslation.Inrecentyears，withthedeepdevelopmentofstudiesonmethyl⁃transferaseanddemethylase，moreandmorestudieshavefoundthatmethyl-bindingproteinplaysanimportantroleinthemethylationmodificationofm6ARNA.TheYT521-Bhomology（YTH）domain-containingprotein1（YTHDC1），astheonlyintranuclearRNAm6Amethylatedbindingproteininthem6AmodifiedYTHdomainfamilyofmethyl-bindingpro⁃teins，hasarelativelyuniqueroleinselectivesplicingandnuclearexport，aswellasregulatingRNAstabilityanddegrada⁃tion.Furthermore，itplaysaveryextensiveandimportantroleinregulatingtheoccurrenceanddevelopmentofmanydis⁃eases.ThispaperreviewstheeffectsofYTHDC1onthepathogenesisofdiseasesandthespecificmechanisms，soastofur⁃therunderstandtheimportanceofYTHDC1inregulatingtheoccurrenceanddevelopmentofthediseases.［关键词］N6-甲基腺苷；甲基结合蛋白；表观遗传学［KEYWORDS］N6-methyladenosine；methyl-bindingprotein；epigenetics［中图分类号］R394；R363［文献标志码］Adoi：10.3969/j.issn.1000-4718.2023.02.018表观遗传学是指DNA序列不变的情况下，基于非基因序列改变所致的基因表达水平的变化［1］，如DNA甲基化［2］、RNA甲基化［3］、组蛋白修饰［4］、染色质构象变化［5］等。表观遗传学在真核生物中的变化主要是调控细胞增殖［6-7］、分化［8］、代谢［3，9］、周期循环［10］以及免疫调控［11］等生物学过程，这一过程中通过某些调控分子量的变化或发生结构修饰变化等，进而靶向调节下游靶基因...
