中国病理生理杂志ChineseJournalofPathophysiology2023，39（2）：373-378杂志网址：http://www.cjpp.netTRPV4在心血管疾病中作用的研究进展*董倩，俞坤武，杜以梅△（华中科技大学同济医学院附属协和医院心内科，湖北武汉430000）ProgressinroleofTRPV4incardiovasculardiseasesDONGQian，YUKun-wu，DUYi-mei△（DepartmentofCardiology，UnionHospital，TongjiMedicalCollege，HuazhongUniversityofScienceandTechnology，Wuhan430000，China.E-mail：yimeidu@mail.hust.edu.cn）［ABSTRACT］TransientreceptorpotentialcationchannelsubfamilyVmember4（TRPV4）isanon-selectivecationchannelthatiswidelyexpressedinthecardiovascularsystem.ActivationofTRPV4inducesanincreaseinintracel⁃lularcalciumconcentrationandplaysanimportantroleinbothphysiologicalandpathologicalconditions.RecentstudieshaverevealedthatTRPV4playsanimportantroleinmanypathophysiologicalprocessescloselyrelatedtocardiovasculardiseases，includingregulatingvasodilationandprotectingtheintegrityoftheendothelialcellbarrier，etc.Thisreviewdis⁃cussestheevidenceanditspotentialmechanismsofTRPV4indiverseresponsesincludinghypertension，myocardialin⁃farction，cardiacremodeling，congestiveheartfailure-inducedpulmonaryedema，atherosclerosis，andarrhythmia.［关键词］瞬时受体电位阳离子通道V亚家族成员4；心血管疾病；机制［KEYWORDS］TransientreceptorpotentialcationchannelsubfamilyVmember4；Cardiovasculardiseases；Mechanism［中图分类号］R54；R363［文献标志码］Adoi：10.3969/j.issn.1000-4718.2023.02.021瞬时受体电位阳离子通道V亚家族成员4（tran⁃sientreceptorpotentialcationchannelsubfamilyVmember4，TRPV4）是瞬时受体电位阳离子通道（transientreceptorpotentialcationchannel，TRP）家族成员，是一种非选择性阳离子通道，对Ca2+离子具有适中通透性，对Na+和Mg2+少量通透（PCa/PNa约为6~10，PCa/PMg约为2~3）。TRPV4在心血管系统表达广泛，主要表达于血管内皮细胞、血管平滑肌细胞、心肌细胞和成纤维细胞等，可调节血管张力和血管通透性，参与机械信号传导等。已知TRPV4的表达和功能异常，参与了高血压、动脉粥样硬化、心肌缺血再灌注损伤、心力衰竭和肺水肿、心律失常等疾病的发生发展，本文旨在对心血管系统TR...
