超声引导下甲状腺FNAB联合BRAFV600E基因检测对甲状腺微小结节的诊断价值朱莉莎1,2,杜朝阳1,2,黎兵1,2,喻昆霖2,3(1.宜春市人民医院功能科;2.宜春学院附属医院;3.宜春市人民医院普外科,江西宜春336000)摘要:目的:探讨超声引导下甲状腺细针穿刺活检(FNAB)联合丝/苏氨酸特异性激酶基因突变基因V600E(BRAFV600E)检测对甲状腺微小结节的诊断价值。方法:选取2020年10月~2021年10月于我院进行甲状腺切除术患者67例,术前均接受甲状腺FNAB及BRAFV600E基因检测,并与术后病理结果进行比对分析。结果:与术前单一进行FNAB相比,术前FNAB联合BRAFV600E基因检测的术后病理符合率(94.03%),特异度(97.14%),敏感度(90.63%)均高于单一FNAB检查,差异有统计学意义(P<0.05)。结论:超声引导下甲状腺FNAB联合BRAFV600E检测可提高甲状腺微小结节术前检出率,对患者治疗及疾病诊断具有较高的参考价值。关键词:甲状腺微小结节;超声引导;细针穿刺活检;丝/苏氨酸特异性激酶基因突变基因V600E;病理诊断中图分类号:R445.1文献标识码:A文章编号:1671380X(2023)06007604TheDiagnosticValueofUltrasoundguidedFNABExaminationCombinedwithBRAFV600EGeneTestinThyroidMicronodulesZHULisha1,2,DUZhaoyang1,2,LIBing1,2,YUKunlin2,3(1.DepartmentofFunction,YichunPeople’sHospital;2.TheAffiliatedHospitalofYichunUniversity;3.DepartmentofGeneralSurgery,YichunPeople’sHospital,Yichun336000,China)Abstract:Objective:Toinvestigatethediagnosticvalueofultrasoundguidedthyroidfineneedleaspirationbiopsy(FNAB)combinedwiththedetectionofsilk/threoninespecifickinasemutationV600E(BRAFV600E)inthediag-nosisofthyroidmicronodules.Methods:67patientswhounderwentthyroidectomyinourhospitalfromOctober2020toOctober2021wereselected,andallofthemreceivedthyroidFNABandBRAFV600Egenedetectionbeforesur-gery,andcomparedwiththepostoperativepathologicalresults.Results:ComparedwithpreoperativeFNABalone,preoperativeFNABcombinedwithBRAFV600Egenedetectionhadhigherpostoperativepathologicalcoincidencerate(94.03%),specificity(97.14%)andsensitivity(90.63%)thansingleFNABdetection,withstatisticalsignifi-cance(P<0.05).Conclusion:UltrasoundguideddetectionofthyroidFNABcombinedwithBRAFV600Ecanim-provethepreoperativedetectionrateofthyroidmicronodule...
