新发传染病电子杂志2023年6月第8卷第3期ElectronicJournalofEmergingInfectiousDiseases,June2023,Vol.8,No.3·84·通信作者：沈永明，shenymtj@sina.com引用格式：邱方洲，沈永明.肠道病毒感染相关疾病的流行特征研究进展[J/CD].新发传染病电子杂志，2023,8（3）：84-89.QiuFangzhou,ShenYongming.Progressinstudyingtheepidemiccharacteristicsofdiseasesassociatedwithhumanenterovirus[J/CD].ElectronicJournalofEmergingInfectiousDiseases,2023,8(3):84-89.·综述·邱方洲，沈永明（天津市儿童医院检验科，天津300074）肠道病毒感染相关疾病的流行特征研究进展【摘要】人肠道病毒（HEV）能感染人类，引起世界范围的暴发流行，同时可诱发多种临床症状，主要包括发热、头痛、呼吸道感染疾病、咽痛，偶尔还有呕吐和腹泻等症状。有些特定血清型HEV能够引发严重疾病，但大部分HEV感染症状轻微甚至无症状。本文综述了已报道的部分与HEV感染相关疾病包括手足口病、急性弛缓性瘫痪、脑炎脑膜炎、糖尿病、腹泻、呼吸系统疾病、急性出血性结膜炎、急性中耳炎的流行特征研究进展；并进一步总结HEV在不同感染性疾病中的分子流行特征、致病机制进展，阐述HEV与人类感染性疾病的关系。【关键词】人肠道病毒；感染性疾病；流行特征DOI：10.19871/j.cnki.xfcrbzz.2023.03.018【中图分类号】R574ProgressinstudyingtheepidemiccharacteristicsofdiseasesassociatedwithhumanenterovirusQiuFangzhou,ShenYongming(DepartmentofLaboratoryMedical,TianjinChildren'sHospital,Tianjin300074,China)【Abstract】Humanenterovirus(HEV)caninfectpeopleandoutbreakallovertheworld.Atthesametime,itcaninduceavarietyofclinicalsymptoms,includingfever,headache,respiratorytractinfection,sorethroat,andoccasionallyvomitinganddiarrhea.Somespecificserotypescancauseseriousdiseases,butmostoftheHEVinfectionsymptomsaremildorevenasymptomatic.Inthisreview,wewillsummarizetheresearchprogressandcurrentsituationofreporteddiseasesrelatedtoHEVinfection(includinghandfootmouthdisease,acuteflaccidparalysis,encephalitis/meningitis,diabetes,diarrhea,respiratorydiseases,acutehemorrhagicconjunctivitisandacuteotitismedia.FurthersummarizethemolecularepidemiccharacteristicsandpathogenesisofHEVindifferentinfectiousdiseases,andelaboratethe...
