Vol41No1Jan..2023第41卷第1期2023年1月影像科学与光化学ImagingScienceandPhotochemistryhttp://www.yxkxyghx.orgSMI技术联合血清miR-217-5p诊断进展性缺血性脑卒中的研究郑丽娜，解小双，骆周展，唐奇**2022-10-18收稿，2022-11-22录用*通讯作者长沙市第一医院超声科，湖南长沙410005摘要：本研究考察超微血流成像(SMI)技术联合血清miR-217-5p诊断进展性缺血性脑卒中的价值。选择121例急性缺血性脑卒中患者作为研究对象,参照欧洲进展性卒中研究组相关诊断标准将患者分为非进展组(73例)和进展组(48例)。所有患者均进行SMI检查。另外，选择20例男性和10例女性健康体检者作为对照组。通过RT-qPCR检测受试者血清miR-217-5p水平。结果显示，进展组(50.00%)患者颈动脉重度狭窄率高于非进展组(20.55%),P<0.001。进展组患者的SMI分值高于非进展组(P<0.001)。与对照组相比，非进展组和进展组的血清miR-217-5p相对表达量均降低，且进展组低于非进展组(P<0.001)。血清miR-217-5p水平与狭窄程度负相关(=—0.247,5=0006),SMI分值与狭窄程度正相关(r=0.427,P<0.001)。血清miR-217-5p水平和SMI分值联合诊断进展性缺血性脑卒中的ROC曲线下面积(AUC)和特异性高于单独诊断。血清miR-217-5p联合SMI分值诊断进展性缺血性脑卒中的准确性高于两项指标的单独诊断。关键词：超微血流成像；miR-217-5p；进展性缺血性脑卒中；颈动脉狭窄doi：10.7517/issn1674-0475.221023StudyofSMITechniqueCombinedwithSerummiR-217-5pintheDiagnosisofProgressiveIschemicStrokeZHENGLi'na,XIEXiaoshuang,LUOZhouzhan,TANGQi*DepartmentofUltrasound,TheFirstHospitalofChangsha,Changsha410005,Hunan,P.R.ChinaAbstract:Thisstudyinvestigatedthevalueofsuperbmicrovascularimaging(SMI)combinedwithserummiR-217-5pinthediagnosisofprogressiveischemicstroke,121patientswithacuteischemicstrokewereselectedastheresearchsubjects,andthepatientsweredividedintoanon-progressivegroup(73cases)andaprogressivegroup(48cases)accordingtotherelevantdiagnosticcriteriaoftheEuropeanProgressiveStrokeStudyGroup.AlpatientsunderwentSMIexamination.Inaddition20maleand10femalehealthysubjectswereselectedasthecontrolgroup.SerummiR-217-5plevelsofsubjectsweredetectedbyRT-qPCR,Theresultsshowedthattherateofseverecarotidarterystenosisofpatientsintheprogressivegroup(5000...
