第43卷第3期2023年03月Vol.43NO.3MAR.2023赣南医学院学报JOURNALOFGANNANMEDICALUNIVERSITY投稿网址:http://gnyxyxb.gmu.cn血浆蛋白生物标记物在肺动脉高压诊疗中的研究进展盛芸芸1,谢新华2,刘潜3,4(1.赣南医学院基础医学院;2.赣南医学院心脑血管疾病防治教育部重点实验室;3.赣南医学院第一附属医院江西省脉管性疾病临床医学研究中心,江西赣州341000;4.江西中医药大学江西省血管瘤中医药防治重点研究室,江西南昌330000)摘要:肺动脉高压是由多种病因通过不同发病机制引起肺血管结构或功能改变,导致肺血管阻力和肺动脉压力升高,继发右心功能不全甚至右心衰竭的临床综合征,其发病机制复杂、病死率高、早期诊断方法匮乏。因此,探寻潜在的血浆生物标记物对肺动脉高压的早期诊断、临床分型、精准治疗和预后判断、药物靶标识别、药物反应等意义重大。本文主要对肺动脉高压潜在的血浆蛋白质生物标记物进行综述。关键词:肺动脉高压;血浆蛋白质;生物标记物中图分类号:R544.1文献标志码:A文章编号:1001-5779(2023)03-0235-06DOI:10.3969/j.issn.1001-5779.2023.03.003开放科学(资源服务)标识码(OSID):ResearchprogressofplasmaproteinbiomarkersinthediagnosisandtreatmentofpulmonaryhypertensionSHENGYun-yun1,XIEXin-hua2,LIUQian3,4(1.SchoolofBasicMedicine,GannanMedicalUniversity;2.KeyLaboratoryoftheMinistryofEducationforthePreventionandTreatmentofCardiovascularandCerebrovascularDiseases,GannanMedicalUniversity;3.JiangxiProvincialClinicalResearchCenterforVascularAnomalies,TheFirstAffiliatedHospitalofGannanMedicalUniversity,Ganzhou,Jiangxi341000;4.JiangxiKeyLaboratoryofTCMforPreventionandTreatmentonHemangioma,JiangxiUniversityofChineseMedicine,Nanchang,Jiangxi330000)Abstract:Pulmonaryhypertensionisaclinicalsyndromecausedbyavarietyofcausesthroughdifferentpathogenesis,whichleadstochangesinthestructureorfunctionofpulmonaryvessels,resultinginincreasedpulmonaryvascularresistanceandpulmonaryarterypressure,secondarytorightheartinsufficiencyandevenrightheartfailure.Itspathogenesisiscomplex,mortalityishigh,andearlydiagnosismethodsarescarce.Therefore,exploringpotentialplasmabiomarkersisofgreatsignificancefortheearlydiagnosis...