53第35卷第2期2023年VOL.35NO.22023菏泽医学专科学校学报JOURNALOFHEZEMEDICALCOLLEGEDOI:10.3969/j.issn.1008-4118.2023.02.014布地奈德联合维生素D3对小儿哮喘的应用效果董红梅（鄄城县人民医院，山东菏泽274600）摘要：目的探讨小儿哮喘治疗中布地奈德联合维生素D3的应用效果。方法选择我院收治的小儿哮喘患儿80例，随机数字表法将患儿分为观察组和对照组，每组40例。对照组采用布地奈德雾化治疗，观察组在对照组的基础上联合使用维生素D3，比较两组患儿治疗效果、症状和体征消失时间、治疗前后外周血血清免疫球蛋白水平和治疗前后炎性因子表达水平。结果观察组治疗有效率明显高于对照组（P<0.05）；观察组咳嗽、气促、喘鸣音和肺部啰音消失时间均明显短于对照组（P<0.05）；治疗后观察组IgA、IgG和IgM水平均明显高于对照组（P<0.05）；治疗后观察组IL-6、IL-4表达水平明显低于对照组（P<0.05），IFN-γ表达水平明显高于对照组（P<0.05）。结论小儿哮喘治疗中应用布地奈德联合维生素D3可以有效改善患儿肺部啰音等临床症状和体征，降低患儿炎性因子水平和改善患儿免疫功能，效果显著。关键词：小儿哮喘；布地奈德；维生素D3；肺部啰音中图分类号：R256.12文献标识码：A文章编号：1008-4118（2023）02-0053-04EffectofbudesonidecombinedwithvitaminD3onchildrenwithasthmaDONGHongmei(People'sHospitalofJuanchengCounty,Heze274600,Shandong)Abstract:ObjectiveToinvestigatetheeffectofbudesonidecombinedwithvitaminD3inthetreatmentofchildhoodasthma.Methods80casesofchildrenwithasthmainourhospitalwererandomlydividedintotheobservationgroupandthecontrolgroup,40casesineachgroup.Thecontrolgroupwastreatedwithbudesonideatomization,andtheobservationgroupwastreatedwithvitaminD3onthebasisofthecontrolgroup.Theeffect,disappearancetimeofsymptomandsign,thelevelofperipheralbloodserumimmunoglobulinbeforeandaftertreatment,thelevelofinflammatoryexpressionbeforeandaftertreatmentwerecomparedbetweenthetwogroups.ResultsTheeffectiverateoftheobservationgroupwassignificantlyhigherthanthatofthecontrolgroup(P<0.05).Thedisappearancetimeofcough,shortnessofbreath,wheezingandlungraleintheobservationgroupwassignificantlyshorterthanthoseinthecontrolgroup(P<0.05).Aftertreatment,thelevelsofIgA,IgGandIgMin...
