DO1:1O.38468.2023.03.008临床研究著232JDiagnTherDermato-Venereol,Jun.2023.Vol.30,No.3苯扎氯铵消毒液引起的相关皮炎的临床及病理特征：附7例报告张倩，袁立燕，薛汝增，文玮，凌诗琪，吉苏云南方医科大学皮肤病医院，广东广州510091[摘要]目的分析7例苯扎氯铵消毒液引起的皮炎病例的临床表现及组织病理特征,增强对该病的认识。方法收集2022年8一11月至南方医科大学皮肤病医院就诊的7例因接触苯扎氯胺消毒液引起的相关皮炎患者资料,对其临床表现及病理资料进行回顾性分析。结果7例患者临床表现为间擦部位皮肤反复环状红斑、脱屑。4例完成组织病理检查，均可见海绵形成、棘层肥厚、真皮浅层血管周围炎，其中2例可见表皮及真皮中性粒细胞聚集。治疗上避免再次接触苯扎氯铵消毒液，系统应用糖皮质激素及环孢素。结论苯扎氯铵消毒液引起的皮炎表现特异，治疗效果佳，确诊需进一步完善斑贴试验。[关键词]］皮炎；苯扎氯胺；帅临床表现；病理特征SevencasesofdermatitiscausedbybenzalkoniumchloridedisinfectantZHANGQian,YUANLiyan,XUERuzeng,WENWei,LINGShiqi,JISuyunDermatologyHospital,SouthernMedicalUniversity,Guangzhou510091,ChinaCorrespondingauthor:JISuyun,E-mail:gddhjisuyun@smu.edu.cn[Abstract]ObjectiveToanalyzetheclinicalmanifestationsandhistopathologicalfeaturesof7casesofdermatitiscausedbybenzalkoniumchloridedisinfectant,soastoenhancetheunderstand-ingofthisdisease.MethodsWeretrospectivelyanalyzedtheclinicalmanifestationsandpatho-logicalfeaturesofbenzalkoniumdisinfectant-inducedcontactdermatitisin7caseswhovisitedourclinicfromAugusttoNovember2022.ResultsTheclinicalmanifestationswererepeatedannu-larerythemaanddesquamationattherubbingsitesoftheskin.Thehistopathologicalfeaturesof4caseswerespongeformation,acanthosisandperivascularinflammationinthesuperficialdermis.Accumulationofneutrophilsintheepidermisandthedermiswasobservedin2cases.Patientsweretreatedwiththesystemicglucocorticoidsandcyclosporine,andadvisedtoavoidcontactwithbenzalkoniumchloridedisinfectant.ConclusionsContactdermatitiscausedbybenzalkoniumchloridedisinfectanthasspecificmanifestationsandgoodresponsetothetreatments.Theskinpatchtestwouldbehelpfultoconfirmthediagnosis.[Keywords]der...
