综述272JDiagnTherDermato-enereol,Jun.2023.Vol.30,No.3病原微生物在硬皮病发病机制中的作用刘若的12，张力天？，张悦12，杨斌1.21.广东医科大学，广东湛江524023；2.南方医科大学皮肤病医院，广东广州510091[摘要]系统性硬皮病（SSc）是一种以皮肤局部或广泛变硬和内脏进行性硬化为特点的自身免疫性结缔组织病。该病的发病机制尚未完全阐明，目前认为可能与环境因素诱发、表观遗传调控以及免疫系统紊乱有关。本文对病原微生物在硬皮病发病机制中的作用研究进展进行综述，表明病毒、细菌、支原体、寄生虫等病原微生物均可诱发硬皮病，人类疱疹病毒属及B19V、HBV等病毒可造成内皮功能障碍及成纤维细胞活化等病理改变，人体内外的微生物群的改变也与SSc病情转变相关，感染伯纳特氏立克次体、支原体和刚地弓形虫、棘球坳后出现的SSc可在抗病原体治疗后好转，这为SSc的发病机制探索开拓思路，为疾病的早期识别、干预和治疗提供新的启示[关键词]系统性硬皮病；病毒；细菌；寄生虫TheroleofpathogenicmicroorganismsinthepathogenesisofsclerodermaLIURuoyun'-2,ZHANGLiian',ZHANGYue'-2,YANGBinl.21.GuangdongMedicalUniversity,Zhanjiang524023,China;2.DermatologyHospital,SouthernMedicalUniversity,Guangzhou510091,ChinaCorrespondingauthor:YANGBin,E-mail:yangbinl@smu.edu.cn[Abstract]Systemicsclerosis(SSc)isanautoimmuneconnectivetissuediseasecharacterizedbylocalizedorwidespreadsclerosisoftheskinandprogressivesclerosisintheinternalorgans.Thepathogenesisofthisdiseasehasnotbeencompletelyelucidated.However,itisconsideredtobeassociatedwithenvironmentalfactors,epigeneticmechanisms,anddisordersoftheimmunesystem.Thisarticlereviewstheresearchprogressontheroleofpathogenicmicroorganismsinthepathogenesisofscleroderma.Ithasbeenshownthatsclerodermacanbeinducedbyinfectionswithviruses,bacteria,mycoplasma,parasites,andotherpathogenicmicroorganisms.Humanherpes-virusandvirusessuchasB19VandHBVcancausepathologicalchangessuchasendothelialdys-functionandfibroblastactivation.AlterationsinthemicrobiotainsideandoutsidethebodyarealsoassociatedwithSSc.TreatmentsofpathogenicmicroorganismsimproveSScassociatedwithinfec-tionsbypathogenicmicroorganismssuchasCburneti,Mycoplasmaandparasites,...
