D0I:10.3969/j.issn.1674-8468.2023.03.020综述296JDiagnTherDermatoJun.2023.Vol.30,No.3lereoHippo信号通路在皮肤恶性肿瘤中的研究进展曹雪，董灵娣，马马韶鸿？，张文涛²，喻楠?1.巴彦淖尔市医院，内蒙古自治区临河015000；2.宁夏医科大学总医院，宁夏回族自治区银川750000[摘要]皮肤恶性肿瘤的经典靶向治疗存在疗效衰减、耐药及复发等问题，寻找新的治疗靶点对皮肤恶性肿瘤患者意义重大。Hippo信号通路在肿瘤增殖、侵袭、耐药、免疫中发挥重要作用,Hippo信号通路靶向药物在皮肤恶性肿瘤联合治疗中展现了良好的应用前景，被认为是未来解决靶向治疗过程中出现的疗效衰减及耐药性问题的有效途径。本文综述Hippo通路在皮肤恶性肿瘤中的生理过程及潜在作用机制，并讨论该通路在靶向联合治疗中的作用及意义。[关键词]Hippo信号通路；·YAP结合蛋白；皮肤恶性肿瘤；靶向治疗AdvancesinHippopathwayinmalignantskintumorsCAOXue',DONGLindi?,MAShaohong’,ZHANGWentao?,YUNan?1.BayannurHospital,Linhe015000,China;2.GeneralHospitalofNingxiaMedicalUniversity,Yinchuan750000,ChinaCorrespondingauthor:YUNan,E-mail:13895095009@163.com[Abstract]Theclassictargetedtherapyforskinmalignanttumorshasissuessuchasefficacyat-tenuation,drugresistance,andrecurrence.Findingnewtreatmenttargetsisofgreatsignificanceforpatientswithskinmalignanttumors.TheHipposignalingpathwayplaysanimportantroleintumorproliferation,invasion,drugresistanceandimmunity.TargeteddrugsthroughtheHipposignalingpathwayhaveshowngoodapplicationprospectsinthecombinationtherapyofskinmalig-nanttumors,andareconsideredasaneffectivewaytosolvetheproblemsofefficacyattenuationanddrugresistanceintargetedtherapyinthefuture.Thisarticlereviewsthephysiologicalproces-sesandpotentialmechanismsofHippopathwayinskinmalignanttumors,anddiscussesitsroleandsignificanceintargetedcombinationtherapy.[Keywords]Hipposignalingpathway;YAP-bindingprotein;malignantskintumors;tar-getedtherapy近年来，随着人口老龄化、臭氧层变薄以及户外活动的增多,皮肤恶性肿瘤的发病率逐年上升，近年来用于治疗皮肤恶性肿瘤的花费在所有恶性肿瘤中排第4位，仅次于乳腺癌、结直肠癌和肺癌，且未来仍将呈增长趋势因此，深人研究皮肤肿瘤相关通路的调控机制，不断...
