CENPN对头颈鳞状细胞癌患者预后的预测价值研究陈河林1,2舒佳玉1董强2*1.贵州医科大学口腔医学院贵州贵阳550004;2.贵州医科大学附属口腔医院修复种植科贵州贵阳550004[摘要]目的:探讨CENPN在头颈鳞状细胞癌(headandnecksquamouscellcarcinoma,HNSCC)中的表达和其对预后的影响。方法:通过TCGA数据库检索CENPN在HNSCC中的表达水平。选取贵州医科大学附属口腔医院2018~2020年收治的42例HNSCC患者癌组织标本,采用免疫组织化学法检测CENPN的表达,分析CENPN与HNSCC患者临床病理特征和预后的关系。结果:CENPN在HNSCC中表达上调,差异有统计学意义(P<0.05)。CENPN高表达与HNSCC患者病理分级密切相关(P<0.05)。单因素和多因素回归分析结果显示,年龄、T分类和CENPN高表达是HNSCC的独立预后影响因素。Kaplan-Meier曲线分析表明CENPN高表达患者总体生存率更低(P<0.05)。结论:CENPN在HNSCC中表达上调,可作为独立生物学标志物预测HNSCC患者预后。[关键词]CENPN;头颈鳞状细胞癌;预后[文献标识码]A[文章编号]1671—7651(2023)08—0690—06[doi]10.13701/j.cnki.kqyxyj.2023.08.006StudyonPrognosticValueofCENPNinHeadandNeckSquamousCellCarcinoma.CHENHelin1,2,SHUJiayu1,DONGQiang2*.1.SchoolofStomatology,GuizhouMedicalUniversity,Guiyang550004,China;2.Depart-mentofProstheticsandImplant,StomatologicalHospitalofGuizhouMedicalUniversity,Guiyang550004,China.[Abstract]Objective:ToinvestigatetheexpressionandprognosticvalueofCENPNinheadandnecksquamouscellcarcinoma(HNSCC).Methods:TheexpressionlevelofCENPNinHNSCCwasevaluatedinTCGAdatabase.Forty-twocancertissuesresectedfromHNSCCpatientswhoadmittedtotheStomatologicalHospitalofGuizhouMedicalUniversitywerechosentomeasureCENPNexpressionbyimmunohistochemistry.TherelationshipbetweenCENPNandclinicopathologicfeatureaswellasprognosiswasanalyzed.Results:TheexpressionlevelofCENPNwassignificantlyup-regulatedinHNSCC(P<0.05).HighexpressionofCENPNwasassociatedwithpathologicalgrade.Univariateandmultivariateregressionanalysisdemonstratedthatage,Tstage,andhighexpressionofCEN-PNwereindependentprognosticfactorsinHNSCC.Kaplan-MeieranalysisshowedthathigherexpressionofCEN-PNwasassociatedwithloweroverallsurvivalrate(P<0.05).Conclusion:CENPNwasup-regulat...
