—761—第9期第53卷2023-02-23孙轶群，硕士生，Email：1377751332@qq.com。赵军招，主任医师，Email：z.joyce08@163.com。收稿日期：作者简介：通信作者：Kisspeptin在辅助生殖过程中的研究进展孙轶群，赵军招温州医科大学附属第二医院生殖医学中心，浙江温州325000[摘要]Kisspeptin是一种神经肽类物质，通过与KISS1R（G蛋白偶联受体）结合，刺激促性腺激素释放激素释放，进而调控下丘脑-垂体-性腺轴，在女性生殖过程中发挥重要的作用。除下丘脑之外，卵巢、子宫内膜、滋养层等组织与细胞中也发现kisspeptin及其受体KISS1R的表达，局部表达的kisspeptin/KISS1R参与多种生理活动，对卵细胞成熟、胚胎着床等过程意义重大。本文主要就kisspeptin在生殖相关领域，尤其是排卵及着床过程中的进展进行综述，并简述kisspeptin在预测妊娠结局，以及生殖相关疾病如反复移植失败和复发性流产等的潜在意义，以期为kisspeptin在辅助生殖技术中的应用提供思路。[关键词]kisspeptin；卵巢；胚胎着床；辅助生殖[中图分类号]R715.2DOI:10.3969/j.issn.2095-9400.2023.09.013AdvancesinthestudyofkisspeptininassistedreproductionSUNYiqun,ZHAOJunzhao.DepartmentofReproductiveCenter,theSecondAffiliatedHospitalofWenzhouMedicalUniversity,Wenzhou325000,ChinaAbstract:KisspeptinisaneuropeptidethatregulatesfemalereproductionbybindingtotheGprotein-coupledreceptorKISS1Randstimulatinggonadotropin-releasinghormonerelease,whichinturnregulatesthehypothalamic-pituitary-gonadalaxis.Inadditiontothehypothalamus,kisspeptinanditsreceptorKISS1Rarealsofoundtobeexpressedintheovary,endometrium,trophectodermandothertissuesandcells.Thelocallyexpressedkisspeptin/KISS1Rinvolvedinavarietyofphysiologicalactivitiesissignificantforoocytematurationandembryoimplantation.Inthispaper,wereviewtheprogressofkisspeptininreproduction-relatedfields,particularlyovulationandimplantation,andbrieflydiscusskisspeptin’spotentialsignificanceinpredictingpregnancyoutcomeandreproduction-relateddiseasessuchasrecurrenttransferfailureandrecurrentmiscarriage,inordertoprovideideasforkisspeptin’sapplicationinassistedreproductivetechnology.Keywords:kisspeptin;ovary;embryoimplantation;assistedreproduction本文引用：孙轶群，...
