心血管康复医学杂志2023年8月第32卷第4期ChinJCardiovascRehabilMed，August2023，Vol.32No.4low-dosesacubitriland/orvalsartanonrenaldiseaseinsalt-sensitivehypertension[J].AmJPhysiolRenalPhysiol,2020,319(1):F63-F75.[32]BhattDL,KandzariDE,ONeillWW,etal.Acontrolledtrialofrenaldenervationforresistanthypertension[J].NEnglJMed,2014，370（15):1393-1401.[33]GongL,JiangF,ZhangZ,etal.Catheter-BasedRenalDenervationAttenuatesKidneyInterstitialFibrosisinaCanineModelofHigh-FatDiet-InducedHypertension[JJ.KidneyBloodPressRes,2019，44(4):628-642.[34JNaduvathumuriyilT,HeldU,SteigmillerK,etal.Clinicalbenefitsandsafetyofrenaldenervationinseverearterialhyper-tension:Along-termfollow-upstudy[J].JClinHypertens(Greenwich)，2020,22（10):1854-1864.[35]WeberMA,KirtaneAJ,WeirMR,etal.TheREDUCEHTN:REINFORCE:Randomized,Sham-ControlledTrialof387BipolarRadiofrequencyRenalDenervationfortheTreatmentofHypertension[J].JACCCardiovascInterv,2020,13（4):461-470.[36]LipphardtM,KoziolekMJ,LehnigLY,etal.Effectofbaroreflexactivationtherapyonrenalsodiumexcretioninpa-tientswithresistanthypertension[J].ClinResCardiol,2019,108(11):1287-1296.[37]WallbachM,ZurbigP,DihaziH,etal.Kidneyprotectiveeffectsofbaroreflexactivationtherapyinpatientswithresistanthypertension[J].JClinHypertens（Greenwich),2018,20(10):1519-1526.[38]WallbachM,HalbachM,ReuterH,etal.Baroreflexactiva-tiontherapyinpatientswithpriorrenaldenervation[JJ.JHy-pertens,2016,34(8):1630-1638.(收稿日期：2021-01－21)GDF一15在心血管疾病中作用的研究进展张秀华，马丹摘要：目前对心血管疾病（CVD）的研究发现，在病理或应激条件下，心肌细胞中生长分化因子（GDF）一15的表达和分泌增加，对抑制心脏重构及心肌凋亡起有益作用，有望成为CVD的临床治疗新靶点。而且研究表明GDF-15可预测CVD的发生发展，可作为诊断CVD及评估预后的新型生物标志物。本文就GDF-15在CVD中的作用的研究进展作一综述。关键词：心血管疾病；生长分化因子类；预测文章编号：1008-0074（2023）04-387-05Doi:10.3969/j.issn.1008-0074.2023.04.15ResearchprogressonroleofGDF-15incardiovasculardiseases/ZHANGXiu-hua,MADan//CriticalCareUnit,D...
