immunohistochemistrywasperformedtoinvestigatetheexpressionofKi67.ResultsTERTpromotermutationwascorrelatedwithpatientage,tumorsize,stromacellularity,atypia,mitoticfigures,andKi67index,etc.TheincidenceofTERTpromotermutationsinfibroadenomas(116%,5/43)waslowerthanthatinphyllodestumors(485%,16/33).ConclusionTERTpromotermutationiscloselyrelatedtotheclinicopathologicalparametersofbreastfibrousepithelialtumors,andTERTpromotermutationdetectionisofgreatsignificanceinthedifferentialdiagnosisofbreastfibroepithelialtumors.Keywords:breastfibroadenoma;breastphyllodestumor;TERTpromoter;Sangersequencing网络出版时间:2023-08-2412:53:50网络出版地址:https://link.cnki.net/urlid/34.1073.R.20230824.0903.011EphB2调控claudin6对子宫内膜癌侵袭和转移的影响孙帅1,2,夏青1,2,李凡1,2,闵锐1,2,韩悦心3,冯振中4,李楠1,2,4摘要:目的探讨EphB2和claudin6的靶向关系,观察敲低和过表达EphB2基因通过调控claudin6对子宫内膜癌细胞生长、迁移及侵袭的影响。方法采用TCGA数据库分析EphB2在子宫内膜癌和癌旁组织中的差异表达及其与临床病理特征的关系;应用GSEA法预测EphB2可能相关的功能通路;应用TCGA数据库分析EphB2互作基因;利用体外培养子宫内膜癌细胞;采用脂质体转染法转染子宫内膜癌细胞敲低和过表达EphB2基因;采用qRTPCR法和Westernblot法检测敲...