http://XBYZ.cbpt.cnki.net阿法骨化醇联合西那卡塞治疗血液透析继发性甲状旁腺功能亢进症的疗效朱丹,刘胜阳,张宝桐,张绎平辽阳市中心医院透析室,辽阳111000摘要:目的探究阿法骨化醇联合西那卡塞治疗血液透析继发性甲状旁腺功能亢进症的临床疗效及对患者血磷、血钙、甲状旁腺素(parathyroidhormone,PTH)水平的影响。方法选取维持性血液透析继发性甲状旁腺功能亢进症患者78例,用随机数字表法分为对照组和观察组,每组39例。2组患者均给予阿法骨化醇治疗,观察组加用西那卡塞,持续3个月。比较治疗前、后患者血钙、血磷、PTH、碱性磷酸酶(alkalinephosphatase,ALP)和甲状旁腺体积的变化,并记录治疗过程中不良反应的发生情况。结果治疗3个月后,观察组的治疗有效率(89.75%)显著高于对照组(71.79%)(P<0.05);2组患者的血钙水平较治疗前均升高,且观察组低于对照组(P<0.05);2组患者的血磷水平较治疗前均降低,且观察组低于对照组(P<0.05);2组患者的PTH和ALP水平较治疗前均降低,且观察组低于对照组(P<0.05);2组患者甲状旁腺的长、宽、厚和体积较治疗前均减小,且观察组小于对照组(P<0.05)。观察组不良反应的发生率(10.26%)低于对照组(30.77%)(P<0.05)。结论阿法骨化醇联合西那卡塞治疗血液透析继发性甲状旁腺功能亢进疗效显著,可有效改善患者的血钙、血磷、ALP和PTH水平,同时降低不良反应的发生率。关键词:阿法骨化醇;西那卡塞;血液透析继发性甲状旁腺功能亢进症;血钙;血磷;全段甲状旁腺激素DOI:10.3969/j.issn.1004-2407.2023.05.022中图分类号:R973文献标志码:A文章编号:1004-2407(2023)05-0125-05Curativeeffectofalfacalcidolcombinedwithcinacalcetonsecondaryhyperparathy-roidismtohemodialysisZHUDan,LIUShengyang,ZHANGBaotong,ZHANGYipingDialysisRoom,LiaoyangCentralHospital,Liaoyang111000,ChinaAbstract:ObjectiveToexploretheclinicalcurativeeffectofalfacalcidolcombinedwithcinacalcetinpatientswithsecondaryhyper-parathyroidism(SHPT)undergoinghemodialysisanditsinfluencesonthelevelsofbloodphosphorus,calciumandparathyroidhormone(PTH).MethodsAtotalof78maintenancehemodialysis(MHD)patientswithSHPTwereenrolled,anddividedintocontrolgroupandtheobservationgroupaccordingtorandomnumbertablemethod,39casesineachgroup.Thebothgroupsweretreatedwithalfacalcidol,andobservationgroupwasadditionallytreatedwithcinacalcetfor3m...
