α-突触核蛋白通过诱发内质网应激促进帕金森病的进展*全水悦,鲍丽娓,申东方,曾鹏慧,张淑岩△(哈尔滨医科大学附属第四医院,哈尔滨150001)摘要帕金森病(Parkinson'sdisease,PD)是世界上第二常见的神经退行性疾病,发病率呈逐年上升趋势,其病理特征是α-突触核蛋白(α-synuclein,α-Syn)的异常聚集。内质网在维持蛋白质稳态中起重要作用,许多研究表明该细胞器参与了PD及其他神经退行性疾病的进展。病理情况下,包括α-Syn在内的各种未折叠或异常折叠蛋白可能引起内质网应激(endoplasmicreticulumstress,ERS),干扰细胞正常功能,然而α-Syn诱发ERS的分子机制尚未完全明确。本文旨在概述PD进程与病理性α-Syn和ERS的相关性,以及目前的治疗研究进展,为PD的诊断和治疗提供新思路。关键词帕金森病;α-突触核蛋白;内质网应激;未折叠蛋白反应中图分类号R338;R742α-SynucleinPromotestheProgressionofParkinson'sDiseasebyInducingEndoplasmicReticulumStress*QUANShui-Yue,BAOLi-Wei,SHENDong-Fang,ZENGPeng-Hui,ZHANGShu-Yan△(TheFourthHospitalofHarbinMedicalUniversity;Harbin150001,China)AbstractParkinson'sdisease(PD)isthesecondmostcommonneurodegenerativediseaseworld-wide,withanincreasingincidenceovertheyears.Itspathologyischaracterizedbytheabnormalaggregationofα-synuclein(α-Syn).Theendoplasmicreticulumplaysacriticalroleinmaintainingproteinhomeostasis,andnumerousstudieshaveshownitsinvolvementintheprogressionofPDandotherneurodegenerativediseases.Underpathologicalconditions,variousunfoldedormis-foldedproteins,includingα-Syn,maycauseendoplasmicreticulumstress(ERS)andinterferewithnormalcellularfunction.However,themolecularmechanismofERSinducedbyα-Synhasnotbeenfullyelucidated.Thearticleaimstosummarizethecorrelationofα-SynandERSwiththeprogressionofPD,aswellasthecurrentprogressintherapeuticresearch,thusprovidingnewinsightsforthediagnosisandtreatmentofPD.KeywordsParkinson'sdisease;α-synuclein;endoplasmicreticulumstress;unfoldedproteinre-sponse引用格式:全水悦,鲍丽娓,申东方,曾鹏慧,张淑岩.α-突触核蛋白通过诱发内质网应激促进帕金森病的进展.生理科学进展,2023,54(4)︰312~318QUANShui-Yue,BAOLi-Wei,SHENDong-Fang,ZENGPeng-Hui,ZHANGShu-Yan.α-SynucleinPromotesthePr...
