论著伤害医学(电子版)2023年6月,12(2):40-45ISSN2095-1566CN11-9306/RDOl:10.3868/j.issn.2095-1566.2023.02.007标准大骨瓣开颅减压术对重型颅脑损伤的治疗效果分析陈盾渊,韩明对*汕头大学医学院第二附属医院急诊科,汕头515041摘要:目的探究标准大骨瓣开颅减压术对重型脑损伤的治疗效果。方法回顾性选取2021年3月至2022年3月某院收治的98例重型颅脑损伤患者为研究对象,50例采用标准大骨瓣开颅减压术治疗的患者为研究组,48例采用常规骨瓣开颅减压术治疗的患者为对照组。比较两组的疗效、术后并发症、颅内压、卒中评分(NationalInstituteofHealthstrokescale,NISS)、格拉斯哥昏迷评分(glasgowcomascale,GCS)、神经功能。结果研究组的生存率高于对照组,术后并发症总发生率低于对照组(P<0.05);两组术后3d、7d的颅内压、术后1周的NISS评分、胶质纤维酸性蛋白(glialfibrillaryacidicprotein,GFAP)均低于术前,且研究组低于对照组(P<0.05);两组术后1周的GCS评分、神经生长因子(nervegrowthfactor,NGF)均高于术前,且研究组高于对照组(P<0.05)。结论对于治疗重型颅脑损伤,标准大骨瓣开颅减压术相较常规骨瓣开颅减压术其疗效更佳,能有效提高患者神经功能、生存率及生存质量,降低颅内压,减少患者术后并发症。关键词:标准大骨瓣开颅减压术;重型颅脑损伤;临床疗效EffectofStandardCraniocerebralInjuryLargeCraniotomyDecompressiononSevereCHENDun-yuan,HANMing-dui*EmergencyDepartment,TheSecondAfiliatedHospitalofShantouUniversityMedicalCollege,Guangdong,Shantou515041,ChinaAbstract:ObjectiveToexploretheeffectofstandardlargecraniotomydecompressiononseverecraniocerebralinjury.MethodsFromMarch2021toMarch2022,98patientswithseverecraniocerebralinjurywhoweretreatedintheSecondAffiliatedHospitalwereretrospectivelyselectedasthestudyobjects.Amongthem,50patientstreatedwithstandardlargecraniotomydecompressionweredividedintothestudygroup,and48patientstreatedwithconventionalcraniotomydecompressionasthecontrolgroup.Theefficacy,postoperativecomplications,intracranialpressure,NISSscore(NationalInstituteofHealthstrokescale),Glasgowcomascale(GCS)scoreandneurologicalfunctionwerecomparedbetweenthetwogroups.ResultsThesurvivalrateofthestudygroupwassignificantlyhighertha...