·310.D0I:10.12280/gjszjk.20230089N6-甲基腺嘌呤修饰在卵子发生及早期胚胎发育中的调控作用国际生殖健康/计划生育杂志2023年7月第42卷第4期JIntReprodHealth/FamPlan，July2023,Vol.42,No.4·综述·闻鑫，赵晓丽，栾祖乾,高娜，董融,夏天←【摘要】N6-甲基腺嘌呤（N-methyladenosine,mA）是指RNA腺苷第6位氮（N)原子的甲基化修饰，是哺乳动物mRNA中最为丰富的表观转录组学修饰。m'A依赖于甲基转移酶（Writer）、去甲基化转移酶(Eraser）和mA结合蛋白(Reader)的共同调控作用。诸多研究表明m°A及其调节酶几乎存在于各个发育阶段的卵泡及早期胚胎组织中，凭借其动态、可逆、敏感的特性广泛地参与mRNA的代谢过程，在转录后水平调控卵子发生，早期胚胎的核重编程、谱系分化、种植以及妊娠维持,在很大程度上决定了女性的生育能力和妊娠结局,并有望成为诸多生殖障碍相关疾病的诊断、预后标志物以及新的治疗靶点。【关键词】RNA,信使；卵子发生；胚胎发育；甲基化;N6-甲基腺嘌呤RegulatoryRoleofNe-MethyladenosineModificationinOogenesisandEarlyEmbryonicDevelopmentWENXin,ZHAOXiao-li,LUANZu-qian,GAONa,DONGRong,XIATian.FirstTeachingHospitalofTianjinUniversityofTranditionalChineseMedicine,NationalClinicalResearchCenterforChineseMedicineAcupunctureandMoxibustion,Tianjin300193,ChinaCorrespondingauthor:XIATian,E-mail:xiatian76@163.com[Abstract)Ne-methyladenosine(m°A)referstothemethylationmodificationattheN°positionofadenosineinRNA,whichisthemostabundantepitranscriptomicmodificationinmammalianmRNA.m°Adependsontheco-regulatoryeffectsofmethyltransferase(Writer),demethylase(Eraser)andm°Abindingprotein(Reader).Numerousstudieshaveshownthatm'Aanditsregulatoryenzymesarepresentinthefolliclesandearlyembryonictissuesatalldevelopmentstages,andthatm°AisextensivelyinvolvedinthemRNAmetabolicprocessesbyvirtueoftheirdynamic,reversibleandsensitiveproperties.Therefore,m'Aparticipatesintheregulationofoogenesis,nuclearreprogramming,lineagedifferentiation,implantation,andgestationmaintenanceofearlyembryosatthepost-transcriptionallevel.BecausemAislargelyrelatedtofemalefertilityandpregnancyoutcome,m'Amaybeanewmarkerofdiagnosisandprognosisofmanyreproductivediseases,orap...
