国外医药抗生素分册2023年5月第44卷第3期.173.动物源分离菌异质性耐药研究进展赵冰，梁玉蕾，苑丽*(河南农业大学动物医学院，郑州450046)摘要：细菌耐药性的持续发展是全世界公共卫生难题，结果导致临床医学和畜牧业防控耐药菌感染日益困难，不仅严重威胁了人类健康，而且制约了畜牧业的健康持续发展。异质性耐药是细菌耐药发展的中间环节，在一定条件下能发展为稳定耐药菌，从而进一步加重细菌耐药；同时还会导致临床用药治疗失败，延长病程或影响养殖业的经济效益。本文从异质性耐药菌的分类、危害、检测方法与判定标准、流行病学特征及形成机制进行综述，以期为畜牧业临床诊断与研究异质性耐药菌提供理论依据，并为有效遏制细菌耐药发展提供帮助。关键词：异质性耐药；形成机制；判定标准；流行病学特征；动物源细菌；检测方法中图分类号：R378文献标志码：A文章编号：1001-8751(2023)03-0173-05ReviewsonHeteroresistanceofBacteriaIsolatedfromAnimalsZhaoBing,LiangYu-lei,YuanLi(CollegeofVeterinaryMedicine,HenanAgriculturalUniversity,Zhengzhou450046)Abstract:Thecontinuousdevelopmentofbacterialresistanceisaglobalpublichealthproblem.Asaresult,itisincreasinglydifficulttopreventandcontroldrug-resistantbacterialinfectionsinhumanmedicineandanimalhusbandry,whichnotonlyseriouslythreatenshumanhealth,butalsorestrictsthehealthyandsustainabledevelopmentofanimalhusbandry.Heteroresistance(HR)isanintermediatestageinthedevelopmentofantibioticresistance,whichcandevelopintostabledrug-resistantbacteriaundercertainconditions,thusfurtheraggravatingbacterialresistance.Atthesametime,itwillleadtothefailureofclinicaldrugtreatment,prolongthecourseofdiseaseoraffecttheeconomicbenefitsofstockbreeding.Thisarticlereviewstheclassification,harm,detectionmethodsandcriteria,epidemiologicalcharacteristicsandformationmechanismofheteroresistantbacteria,inordertoprovideatheoreticalbasisforclinicaldiagnosisandresearchofheteroresistantbacteriainanimalhusbandry,aswellasprovidehelpforeffectivelycurbingthedevelopmentofdrugresistance.Keywords:heteroresistance;formationmechanism;criteria;epidemiologicalcharacteristics;bacteriaisolatedfromanimal;detectionmethods通常情况下，细...
