JournalofMinimallyInvasiveUrology,Dec.2022,Vol11,No6前列腺癌靶向穿刺活检中超声引导的研究进展周闪1陈静1牛晓兵2*[摘要]目前,经直肠超声引导下前列腺系统性穿刺活检仍是诊断前列腺癌的金标准。与系统性穿刺活检相比,前列腺靶向穿刺活检可以提高前列腺癌诊断阳性率、减少穿刺针数并减少并发症。随着超声技术的发展,彩色多普勒超声、能量多普勒超声、超声造影、超声弹性成像已普遍应用于前列腺癌的诊断当中,多参数超声在前列腺靶向活检中发挥着越来越重要的作用,为此,本文综述了多参数超声在前列腺癌靶向穿刺活检中的应用进展。[关键词]超声检查;前列腺肿瘤;穿刺术[中图分类号]R737.25[文献标识码]B[DOI]10.19558/j.cnki.10-1020/r.2022.06.013Researchprogressinultrasound-guidedtargetedpuncturebiopsyofprostatecancerZhouShan1ChenJin1NiuXiaobing2*(1DepartmentofUltrasonagraphy,DepartmentofUrology,theAffiliatedHuaianNo.1,People'sHospitalofNanjingMedicalUniversity,Huaian223300,China)Correspondingauthor:NiuXiaobing,nxbhayy@163.comAbstractCurrently,transrectalultrasound-guidedsystematicbiopsyoftheprostateremainsthegoldstandardforthediagnosisofprostatecancer.Comparedwithsystematicbiopsy,targetedprostatebiopsycanimprovetheposi⁃tiverateofprostatecancerdiagnosis,reducethenumberofpuncturestitchesandreducecomplications.Withthede⁃velopmentofultrasoundtechnology,colourDopplerultrasound,energyDopplerultrasound,contrast-enhancedultra⁃soundandultrasoundelastographyhavebeencommonlyusedinthediagnosisofprostatecancer,andmultiparametricultrasoundisplayinganincreasinglyimportantroleintargetedprostatebiopsy.Keywordsultrasonography;prostaticneoplasms;punctures前列腺癌(prostatecancer,PCa)每年约有140万新病例被诊断[1]。目前,我国PCa发病率及死亡率呈逐年上升趋势,PCa的人口标准化发病率为6.25/10万,位居男性全部恶性肿瘤发病第6位[2]。前列腺穿刺活检是诊断PCa的“金标准”[1~5],然而,常规的经直肠超声(transrectalul⁃trasound,TRUS)引导系统穿刺活检方法诊断PCa的灵敏度和特异度约40%~50%,导致临床有意义前列腺癌(clinicallysignifcantprostatecan⁃cer,csPCa)的诊断不足,以及对临床无意义癌(clinicalinsignific...