第53卷第2期2023年2月Vol.53No.2Feb.2023·165·日用化学工业（中英文）ChinaSurfactantDetergent&CosmeticsHydrolysedzinchyaluronan,anovelanti-acnecandidateFanChen1,JunYang2,SupingYang3,YueWu1,*（1.DepartmentofResearchandDevelopment,BloomageBiotechnologyCo.,Ltd.,Shanghai200000,China;2.BIOHYALUXBusinessDivision,BloomageBiotechnologyCo.,Beijing100000,China;3.DepartmentofResearchandDevelopment,BloomageBiotechnologyCo.,Ltd.,Beijing100000,China）Abstract:Inthisstudy,theeffectsofhydrolysedzinchyaluronan（HA-ZN）onlipidproductionandskinhydrationwererevealed.TheHaCaTandSZ95celllineswereappliedtoevaluatethetoxicityandbeneficialeffectofhydrolysedzinchyaluronan.Pro-acneagents,arachidonicacidwasusedtoinducethelipidproductionofSZ95andtheeffectofhydrolysedzinchyaluronanwasdetected.Atthesametime,invitroantibacterialexperimentagainstacne-relatedbacteriaandtheexpressionofskinhydrationinvolvedproteinswereestimated.Attheidenticalconcentrationofzincion,hydrolysedzinchyaluronanexhibitslesstoxicitythanzincchloride,suggestingahighersafedosageofzincion.Inaddition,hydrolysedzinchyaluronanpossessestheabilityofalleviatinglipidproductioninSZ95,aswellasinhibitingthegrowthofPropionibacteriumacnesandMalasseziafurfurinvitro.TheexpressionofAQP3andHAS2isalsoaugmentedinhydrolysedzinchyaluronantreatedgroup.Theresultsindicatethathydrolysedzinchyaluronanmightbeapromisingdrugcandidateagainstacnevulgaris,avertingthesideeffectsofexistingdrugssuchasdryskin.Keywords:acnevulgaris;skinhydration;zincsalt;hydrolysedzinchyaluronanReceived:July21,2022;Revised:February1,2023.*Correspondingauthor.E-mail:wuy@bloomagebiotech.com.DOI：10.3969/j.issn.1001-1803.2023.02.006HAS2AQP3HaCaTcellsSZ95cellsHA-ZNLipidprodution50μm·166·第53卷开发与应用日用化学工业（中英文）痤疮（Acnevulgaris）是最常见的皮肤疾病之一，以黑头、白头、粉刺、丘疹、脓疱、结节和囊肿为基本特征，好发于面部、颈部、上背部、肩部等区域［1］。痤疮还会引起一系列的后遗症，例如色素沉着、疤痕等等，严重地影响患者的生理和心理健康，降低患者的生活质量［2,3］。痤疮的产生...
