·综述·术后谵妄评估和预测的研究进展康猛韩永正郭向阳DOI:10.12089/jca.2023.01.019基金项目:科技创新2030—“脑科学与类脑研究”重大项目(2021ZD0204302-2);北京大学第三医院临床重点项目(BYSYZD2021013)作者单位:100191北京大学第三医院麻醉科通信作者:韩永正,Email:hanyongzheng@bjmu.edu.cn【摘要】术后谵妄(POD)是手术患者常见的并发症,严重影响患者远期认知功能、生理功能和社会功能。既往对POD的评估多以量表为基础,评估结果存在主观性,如何科学客观地进行POD的评估值得深入探究。POD可在早期预测并干预,从而进行有效预防,基于临床预测模型进行POD的风险预测已成为研究热点。本文从神经心理学量表、血清标志物、脑脊液标志物和脑电标志物等多个维度对POD的评估方法进行归纳,并针对POD临床预测模型的预测对象与预测指标进行总结,以期为POD评估和预测提供科学、可行、有效的参考依据。【关键词】术后谵妄;预测指标;评估方法ResearchprogressinevaluationandpredictionofpostoperativedeliriumKANGMeng,HANYong-zheng,GUOXiangyang.DepartmentofAnesthesiology,PekingUniversityThirdHospital,Beijing100191,ChinaCorrespondingauthor:HANYongzheng,Email:hanyongzheng@bjmu.edu.cn【Abstract】Postoperativedelirium(POD)isacommoncomplicationinpatientsundergoingsurgery,seriouslyaffectinglong-termcognitivefunction,physiologicalandsocialfunction.PreviousevaluationsofPODweremostlybasedonscales,whichmakestheresultstobeinfluencedbysubjectivity.ItisworthyofexploringhowtoevaluatePODscientificallyandobjectively.PODcanbepredictedearlyandpreventedef-fectively.ThepredictionofriskofPODbasedonclinicalpredictionmodelhasbecomearesearchhotspot.ThispapersummarizestheevaluationmethodsofPODfrommultipledimensions,suchasneuropsychologicalscale,serummarkers,cerebrospinalfluidmarkersandEEGmarkers,andsummarizesthepredictiveobjectsandindicatorsofPODclinicalpredictionmodel,inordertoprovideascientific,feasibleandeffectiverefer-encebasisforPODevaluationandprediction.【Keywords】Postoperativedelirium;Predictiveindicator;Assessmentmethod术后谵妄(postoperativedelirium,POD)多发生在术后7d内或出院前,多为一过性,但也可持续数小时至数天。Schenning...