中草药2023年3月第54卷第5期ChineseTraditionalandHerbalDrugs2023MarchVol.54No.5·1609·调和肝脾类中药治疗“肠-肝”轴相关疾病作用机制的研究进展贾可欣1,2，李寒2，刘闰平1*1.北京中医药大学中药学院，北京1000292.北京中医药大学生命科学学院，北京100029摘要：“肠-肝”轴相关疾病是一类基于肝脏和肠道相互作用失衡而引起或加重的疾病。传统中医学基于五脏整体观对“肠-肝”轴相关疾病的认知延伸了自身的肝脾概念，调和肝脾类中药对“肠-肝”轴相关疾病亦有积极的治疗效果，契合中医“肝脾同调，治肝实脾”的独特理念。通过对调和肝脾类中药调节肠道微生态及免疫微环境、保护肠道机械屏障、平衡胆汁酸稳态、调节神经递质治疗“肠-肝”轴相关疾病进行系统性回顾，为从“肠-肝”轴角度阐释调和肝脾类中药的现代科学内涵提供新的思路，助力创新中药开发。关键词：“肠-肝”轴；调和肝脾；以肝治肠；以肠治肝；肝肠同治中图分类号：R285文献标志码：A文章编号：0253-2670(2023)05-1609-11DOI:10.7501/j.issn.0253-2670.2023.05.028ResearchprogressonmechanismoftraditionalChinesemedicinewithharmonizingliverandspleenintreatmentof“gut-liver”axisrelateddiseasesJIAKe-xin1,2,LIHan2,LIURun-ping11.SchoolofChineseMaterialMedica,BeijingUniversityofChineseMedicine,Beijing100029,China2.SchoolofLifeScience,BeijingUniversityofChineseMedicine,Beijing100029,ChinaAbstract:“Gut-liver”axisrelateddiseasesareinducedandexacerbatedbyunbalancedinteractionbetweenliverandintestine.Theuniquecognitionof“gut-liver”axisdiseases,whichisbasedonthe“holismoffiveorgans”theory,extendedtheconceptofliverandspleenintraditionalChinesemedicine,withtheeffectivetherapiesofharmonizingtheliverandspleenandcorrelativerepresentativeprescriptionsinclinical,whichalsotalliedwiththeconsensusof“harmonizingtheliverandspleen,curingthelivertoreinforcingspleen”intraditionalChinesemedicine.Therefore,thereviewaimstoofferaninnovativetherapeuticperspectiveforthe“gut-liver”axisdiseasesandhelpthecreativeexploitationoftraditionalChinesemedicinebyelaboratingthescientificconnotationofprescriptionsandherbsthatharmonizetheliverandspleen,whichthroughadjustingtheintestinalmicroecologyandimmunemic...
