江西医药2022年11月第57卷第11期JiangxiMedicalJournal，November2022，Vol57，No11摘要：目的通过观察新发1型糖尿病（Type1diabetesmellitus，T1DM）并酮症酸中毒（Diabeticketoacidosis，DKA）儿童的体液免疫及细胞免疫水平，探讨其免疫状态。方法选取我院住院治疗的新发T1DM并DKA儿童40例为观察组，健康儿童20例为对照组，并测定其免疫球蛋白、细胞因子的水平和淋巴细胞亚群的细胞数与百分数。结果（1）观察组IgA水平较对照组显著性增高(P＜0.05)；IgE、IgG、IgM水平组间差异无统计学意义；（2）观察组IL-1B、IL8、IFN-γ水平较对照组显著性增高(P＜0.05)；IL2R、IL6、IL10、IL17、TNFα水平组间差异无统计学意义；（3）观察组B淋巴细胞及CD4+CD8+双阳性T淋巴细胞较对照组显著性增高(P＜0.05)，NK细胞数较对照显著性降低(P＜0.05)；总T淋巴细胞、T4淋巴细胞、T8淋巴细胞及T4/T8组间差异无统计学意义；结论新发T1DM并DKA儿童存在体液免疫功能异常，部分炎症因子水平增高，并存在B淋巴细胞与T淋巴细胞的双重功能异常，淋巴细胞亚群功能紊乱可能是导致儿童T1DM的重要因素。关键词：1型糖尿病；酮症酸中毒；免疫球蛋白；细胞因子；淋巴细胞亚群中图分类号：R725文献标识码：B文章编号：1006-2238(2022)11-1709-05DOI：10.3969/j.issn.1006-2238.2022.11.001Analysisofimmunefunctionstatusinchildrenwithnew-onsetT1DMandDKAZHOUBin1,YANGYu1,LIUZhiqiang2,etal.JiangxiProvincialChildren'sHospital,TheAffiliatedChildren'sHospitalofNanchangMedicalCollege,1.DepartmentofEn-docrinology,GeneticsandMetabolism,2.DepartmentofLaboratory,3.DepartmentofPediatrics,NANCHANG,330006,CHINA；4.SchoolofMedicine,JiangxiMedicalCollege,NanchangUniversityAbstract：ObjectiveToinvestigatetheimmunestatusbyobservingthehumoralandcellularimmunityandcytokinelevelsinchildrenwithnew-onsettype1diabetesmellitus(T1DM)andketoacidosis(DKA).Method40childrenwithnew-onsetT1DMandDKAhospitalizedinourhospitalwereselectedastheobservationgroup,and20healthychildrenwereselectedasthecontrolgroup.Thelevelsofimmunoglobulins,cytokines,andthenumberandpercentageoflymphocytesubsetsweredetermined.Results(1)ThelevelofIgAintheobservationgroupwassignificantlyhigherthanthatinthenormalcontrolgroup(P<0.05);therewasnostatisticaldiff...
