2023年2月第30卷第2期外周血Th17/Treg与反流性食管炎患者Hp感染及预后的关系分析吴红艳，尚学彬，刘婷利（河南省职工医院消化内科，河南郑州450002）【摘要】目的分析外周血Th17/Treg与反流性食管炎（RE）患者幽门螺杆菌（Hp）感染及预后的关系。方法85例RE患者根据Hp感染情况分为Hp感染组和Hp未感染组，另选取30例健康者作为对照组，比较三组的外周血Th17/Treg水平。统计RE患者的预后，分析外周血Th17/Treg对预后的预测价值。结果Hp感染组的外周血Th17/Treg水平高于Hp未感染组和对照组，Hp未感染组的外周血Th17/Treg水平高于对照组（P＜0.05）。预后不良组的外周血Th17/Treg水平高于预后良好组（P＜0.05）。Logistic回归分析显示，外周血Th17/Treg是影响RE患者预后的危险因素（P＜0.05）。ROC曲线显示，外周血Th17/Treg预测RE患者预后的AUC为0.737。结论外周血Th17/Treg可作为评估RE患者Hp感染情况及预测预后的客观有效指标。【关键词】反流性食管炎；外周血Th17/Treg；幽门螺杆菌；预后中图分类号：R571文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.02.0275AnalysisontheRelationshipsofPeripheralBloodTh17/TregwithHpInfectionandPrognosisofPatientswithRefluxEsophagi-tis//WUHongyan,SHANGXuebin,LIUTingli(DepartmentofGastroenterology,He'nanStaffHospital,Zhengzhou450002,China)[Abstract]ObjectiveToanalyzetherelationshipsofperipheralbloodTh17/Tregwithhelicobacterpylori(Hp)infectionandprognosisofpatientswithrefluxesophagitis(RE).MethodsAccordingtoHpinfection,85REpatientsweredividedintoHp-infectedgroupandHp-uninfectedgroup,and30healthypeoplewereselectedasthecontrolgroup;ThelevelsofperipheralbloodTh17/Tregofthethreegroupswerecompared.TheprognosisofREpatientswascounted,andthevalueofperipheralbloodTh17/Treginpredictionofprognosiswasanalyzed.ResultsThelevelofperipheralbloodTh17/TregofHp-infectedgroupwashigherthanthatofHp-uninfectedgroupandcontrolgroup,andthelevelofperipheralbloodTh17/TregofHp-uninfectedgroupwashigherthanthatofcontrolgroup(P<0.05).PeripheralbloodTh17/Treginthepoorprognosisgroupwashigherthanthatinthegoodprognosisgroup(P<0.05).LogisticregressionanalysisshowedthatperipheralbloodTh17/TregwasariskfactoraffectingtheprognosisofREpatients(P<0.05...
