·综述·DOI:10．3969/j．issn．1001－5256．2023．03．026新型血清学指标在评估转氨酶正常的慢性HBV感染者肝病进展中的作用王源1，刘怀鄂1，丁洁2，王晴晴2，王爱丽1，孙慧1，曹惠11昆明医科大学第一附属医院感染科，昆明650032;2昆明市第三人民医院肝病综合科，昆明650032通信作者:刘怀鄂，liuhuaie@163．com(OＲCID:0000－0003－0962－2474)摘要:抗病毒治疗是国内外慢性乙型肝炎管理指南中改善预后的基础治疗措施。但对于转氨酶正常的慢性HBV感染者，准确评价肝炎进展程度，筛选合适的需要抗病毒的患者成为临床难题。为了能够客观、准确的评价此类患者肝脏炎症活动程度，除了开展传统的肝组织活检外，越来越多的无创评估指标被人们所关注。本文将近年来研究中发现的能够反映正常转氨酶水平的慢性HBV感染者肝脏炎症和/或纤维化程度的新型血清学指标进行综述，希望为此类患者抗病毒决策提供参考。关键词:乙型肝炎，慢性;血清学;转氨酶类基金项目:云南省高层次卫生人才项目(H－2017071);云南省教育厅科学研究基金项目(2021J0239)ＲoleofnewserologicalmarkersinevaluatingtheprogressionofliverdiseaseinpatientswithchronicHBVinfectionandnormalaminotransferasesWANGYuan1，LIUHuaie1，DINGJie2，WANGQingqing2，WANGAili1，SUNHui1，CAOHui1．(1．DepartmentofInfectiousDiseases，TheFirstAffiliatedHospitalofKunmingMedicalUniversity，Kunming650032，China;2．DepartmentofHepatology，TheThirdPeople’sHospitalofKunming，Kunming650032，China)Correspondingauthor:LIUHuaie，liuhuaie@163．com(OＲCID:0000－0003－0962－2474)Abstract:AntiviraltherapyisthebasictreatmentmethodforimprovingprognosisrecommendedinthemanagementguidelinesofchronichepatitisBinChinaandglobally．ForpatientswithchronicHBVinfectionandnormaltransaminases，itisdifficultinclinicalpracticetoaccuratelyevaluatetheprogressionofhepatitisandidentifysuitablepatientswhoneedantiviraltherapy．Inordertoobjectivelyandaccuratelyevaluatethedegreeofliverinflammatoryactivityinsuchpatients，moreandmorenonin-vasiveevaluationindicatorshavebeenusedinadditiontoconventionalliverbiopsy．Thisarticlereviewsthenewserologicalin-dicatorsthatcanreflectthedegreeofliverinflammationand/orfibrosisinpatientswithchronicHBVinfectionandnor...
