2023年2月国际神经病学神经外科学杂志Vol.50No.1第50卷第1期JournalofInternationalNeurologyandNeurosurgeryFeb.2023以脑膜转移为主要表现的隐匿性结肠癌1例及文献报道纪怡璠1,2,3，孟楠1，蒋欣1,3，谢小华1，刘卫刚1，田丛娜4，董艳红1,3，吕佩源1,2,31.河北省人民医院神经内科，河北石家庄0500512.河北医科大学研究生学院，河北石家庄0500173.河北省脑网络与认知障碍疾病重点实验室，河北石家庄0500514.河北省人民医院核医学科，河北石家庄050051摘要：脑膜癌病（MC）是指恶性肿瘤播散或浸润软脑（脊）膜、蛛网膜下腔，而脑实质不受累的一类疾病，为中枢神经系统转移瘤的少见类型，在实体瘤患者中发生率极低。MC起病隐袭，症状复杂无特异性，患者可呈头痛、意识改变及多种神经功能缺损表现，对于原发灶不明而以脑病为首发症状者，极易误诊、漏诊。现就1例以脑膜转移为首发表现、原发灶为结肠腺癌患者的临床资料进行分析，旨在提高对此病的警惕和认识。[国际神经病学神经外科学杂志,2023,50(1):55-58]关键词：脑膜癌病；继发性肿瘤；多颅神经损害；脑脊液；结肠腺癌中图分类号：R739.41DOI：10.16636/j.cnki.jinn.1673-2642.2023.01.011Occultcoloncancerwiththemainmanifestationofleptomeningealmetastasis:AcasereportandliteraturereviewJIYifan1,2,3，MENGNan1，JIANGXin1,3，XIEXiaohua1，LIUWeigang1，TIANCongna4，DONGYanhong1,3，LÜPeiyuan1,2,31.DepartmentofNeurology，HebeiGeneralHospital，Shijiazhuang，Hebei050051，China2.GraduateSchoolofHebeiMedicalUniversity，Shijiazhuang，Hebei050017，China3.HebeiProvincialKeyLaboratoryofCerebralNetworksandCognitiveDisorders，Shijiazhuang，Hebei050051，China4.DepartmentofNuclearMedicine，HebeiGeneralHospital，Shijiazhuang，Hebei050051，ChinaCorrespondingauthor：LÜPeiyuan，Email：peiyuanlu2@163.comAbstract：Meningealcarcinomatosis（MC）isadiseaseofmalignanttumordisseminationorinvasionintheleptomenin-ges/meningesandthesubarachnoidspacewithouttheinvolvementofbrainparenchyma，anditisararetypeofmetastatictu-morofthecentralnervoussystemandhasanextremelylowincidencerateinpatientswithsolidtumor.MCoftenhasanin-sidiousonsetanddisplayscomplexbutnon-specificsymptoms，andpatientsmayhavethemanifestationsofheadache，changeinconscio...
