有机化学ChineseJournalofOrganicChemistryREVIEW*Correspondingauthor.E-mail:panchangduo@jsut.edu.cnReceivedMay20,2022;revisedJune29,2022;publishedonlineAugust10,2022.ProjectsupportedbytheQingLanProjectofJiangsuProvince.江苏省高校青蓝工程资助项目.156http://sioc-journal.cn/©2023ShanghaiInstituteofOrganicChemistry,ChineseAcademyofSciencesChin.J.Org.Chem.2023,43,156～170DOI:10.6023/cjoc202205034综述与进展以7-氮杂吲哚为内在导向基团的N-芳基C—H官能化研究进展袁成潘长多*(江苏理工学院化学化工学院江苏常州213001)摘要内在导向基团是底物中固有的官能团,同时也是产物中的核心结构单元.因此,在C—H官能化反应中,内在导向基团无需事先引入以及事后脱除.在过渡金属催化的N-芳基-7-氮杂吲哚的N-芳基C—H官能化反应中,7-氮杂吲哚往往作为内在的导向基团,借助C—H官能化的反应策略,在N-芳基的邻位引入各种官能团.对过渡金属催化7-氮杂吲哚作为内在导向基的N-芳基C—H官能化的最新研究进展进行了概述.关键词7-氮杂吲哚;内在导向基;C—H活化;过渡金属催化RecentAdvancesintheN-ArylC—HFunctionalizationUsing7-AzaindoleasIntrinsicDirectingGroupYuan,ChengPan,Changduo*(SchoolofChemistryandChemicalEngineering,JiangsuUniversityofTechnology,Changzhou,Jiangsu213001)AbstractTheintrinsicdirectinggroupisafunctionalgroupinthesubstratesandalsoservesasanessentialcomponentinproducts.Thus,thepreinstallationandremovalofdirectinggroupsareavoided.7-Azaindolehasbeenusedasintrinsicdirect-inggroupfortheN-aryl-C—HfunctionalizationofN-arylsunderthecatalysisoftransitionmetals.UtilizingtheC—Hfunc-tionalizationstrategy,numerousfunctionalgroupswereinstalledintotheortho-positionofN-arylsofthecorrespondingN-aryl-7-azaindoles.Inthisreview,therecentachievementsonthetransition-metalcatalyzedN-arylortho-C—Hfunctionali-zationdirectedby7-azaindolearesummarized.Keywords7-azaindole;intrinsicdirectinggroup;C—Hactivation;transition-metalcatalyzedInthepastfewdecades,C—Hfunctionalizationhasbe-comeoneofthemostpopularhotspotsofresearchduetoitshighefficiency,simpleoperation,highatomeconomyandenvironmentallybenignnature.[1]Inthisfield,directedC—Hactivation,whichsh...
