·综述·DOI:10.3969/j.issn.1001-5256.2023.03.033叶酸与肝癌发生发展的关系李应雯1,2a,2b,师丽1,2a,2b,刘敏2a,2b,袁浩2a,2b,郑亚2a,2b,王玉平2a,2b,郭庆红2a,2b1兰州大学第一临床医学院,兰州730000;2兰州大学第一医院a.消化科,b.甘肃省胃肠病重点实验室,兰州730000通信作者:郭庆红,gqh@lzu.edu.cn(ORCID:0000-0002-0438-3948)摘要:迄今为止,肝癌仍是我国高发、恶性程度极高的肿瘤,严重影响我国人民的生命和健康。以往研究发现,肝癌的发生与病毒、吸烟、饮酒及非酒精性脂肪性肝病等诸多因素相关。随着不断探索,越来越多的研究指出,营养因素及生活环境与肝癌的发生发展相关。叶酸作为机体细胞生长和繁殖所必需的营养物质,其在人体内的水平高低均对肿瘤细胞的生长产生影响,与肝癌的关系密不可分。本文对近年来叶酸与肝癌之间关系的研究进展予以综述,以期为肝癌的预防和治疗提供新的参考和依据。关键词:肝肿瘤;叶酸;DNA甲基化;治疗学基金项目:甘肃省自然科学基金(21JR1RA117,20JR5RA347);兰州大学第一医院院内基金(ldyyyn2019-28,ldyyyn2018-54)AssociationoffolicacidwiththedevelopmentandprogressionoflivercancerLIYingwen1,2a,2b,SHILi1,2a,2b,LIUMin2a,2b,YUANHao2a,2b,ZHENGYa2a,2b,WANGYuping2a,2b,GUOQinghong2a,2b.(1.TheFirstClinicalMedicalCollegeofLanzhouUniversity,Lanzhou730000,China;2.a.DepartmentofGastroenterology,b.GansuKeyLaboratoryofGastroenterology,TheFirstHospitalofLanzhouUniversity,Lanzhou730000,China)Correspondingauthor:GUOQinghong,gqh@lzu.edu.cn(ORCID:0000-0002-0438-3948)Abstract:Sofar,livercancerisstillahighlymalignanttumorwithahighincidencerateinChina,anditseriouslyaffectsthelifeandhealthofChinesepeople.Previousstudieshaveshownthatthedevelopmentoflivercancerisassociatedwithvariousfactorssuchasvirus,smoking,drinking,andnonalcoholicfattyliverdisease.Withcontinuousexploration,moreandmorestudieshavepointedoutthatnutritionalfactorsandlivingenvironmentareassociatedwiththedevelopmentandprogressionoflivercancer.Folicacidisanecessarynutrientforcellgrowthandreproduction,anditslevelinhumanbodyhasanimpactonthegrowthoftumorcellsandiscloselyassociatedwithliv...