34第35卷第1期2023年VOL.35NO.12023菏泽医学专科学校学报JOURNALOFHEZEMEDICALCOLLEGEDOI:10.3969/j.issn.1008-4118.2023.01.010杂合型血液净化对尿毒症患者的效果观察周孟，刘彦玲（淅川县人民医院，河南南阳474450）摘要：目的探究杂合型血液净化干预对尿毒症患者钙磷代谢、炎性因子、免疫功能的影响。方法选取我院收治的尿毒症患者122例，随机分为对照组和观察组，每组61例，对照组行单纯血液透析治疗，观察组行杂合型血液净化治疗。对比两组治疗前后β2-微球蛋白（β2-MG）、胱抑素C（CysC）水平、钙磷代谢水平、炎症因子、免疫功能、氧化应激指标水平变化。结果治疗后观察组血清β2-MG、CysC、血磷、血清C反应蛋白、降钙素原、血清CD4+、一氧化氮、总抗氧化能力水平低于对照组（P均<0.05），血钙、CD8+水平水平高于对照组（P均<0.05）。结论应用杂合型血液净化对尿毒症患者进行治疗，能够减轻患者肾损伤和氧化应激损伤，降低炎症反应，改善患者钙磷代谢和免疫功能。关键词：尿毒症；杂合型血液净化；免疫功能；钙磷代谢；炎性因子中图分类号：R692.5文献标识码：A文章编号：1008-4118（2023）01-0034-04EffectofheterozygousbloodpurificationinterventiononpatientswithuremiaZHOUMeng,LIUYanling（XichuanCountyPeople'sHospital,Nanyang474450,Henan）Abstract:ObjectiveToexploretheeffectofheterozygousbloodpurificationinterventiononcalciumandphosphorusmetabolism,inflammatoryfactorsandimmunologicfunctionofpatientswithuremia.Methods122casesofuremiapatientswereselectedandrandomlydividedintothecontrolgroupandtheobservationgroup,61casesineachgroup.Thecontrolgroupwastreatedwithhemodialysisalone,andtheobservationgroupwastreatedwithheterozygousbloodpurification.Thelevelsofβ2-microglobulin(β2-MG),cystatinC(CysC),calciumandphosphorusmetabolism,inflammatoryfactors,immunefunctionandoxidativestressindexesbeforeandaftertreatmentwerecomparedbetweenthetwogroups.ResultsAftertreatment,thelevelsofserumβ2-MG,CysC,bloodphosphoruslevel,CRP,PCT,serumCD4+,nitricoxideandtotalantioxidantcapacityinobservationgroupwerelowerthanthoseincontrolgroup(P<0.05),bloodcalciumandCD8+levelinobservationgroupwashigherthanthatinthecontrolgroup(P<0.05).ConclusionThetreatmentofuremicpatientswit...
